中文摘要：

目的研究血红素加氧酶-1（HO—1）抑制剂锌卟啉（ZnPP）对自发性脑出血（ICH）大鼠脑水肿和远期脑萎缩情况的影响。方法应用立体定向仪同定大鼠，将自体新鲜动脉血100μL往入大鼠的有侧基底节区制作ICH实验动物模型，ICH大鼠分为ZnPP治疗组和DMSO溶剂对照组。部分大鼠在术后3d断头取脑，采用干湿法测定脑组织含水最；部分大鼠在术后28d灌注取脑作形态学分析。结果ICH后3d，ZnPP治疗组同侧肚底节脑组织含水量明显低于DMSO财照组（P〈0．05）。ZnPP治疗组两侧基底节而积差值明显小于I）MSO对照组（P〈0．05）。结论ICH后腹腔内应用HO-1抑制剂ZnPP缓释泵可以减轻ICH大鼠脑水肿程度和远期的脯萎缩。

英文摘要：

Objective To investigate the inhibition of heme oxygenase-1 （HO1） inhibitor on brain edema and long term effects on brain atrophy after intracerebral hemorrhage （ICH） in rats. Methods 24 male Sprague Dawley rats received an intracerebral injection of 100 μL autologous blood. They were randomized into model group treated with Zinc Protoporphyrin （ZnPP） and DMSO control group. Parts of the rats＇ brain removed at day 3 after ICH were assessed for regional brain water content; parts of the rats brain removed at day 28 after ICH were performed computer assisted morphometric analyses. Results lay treatment with intraperitoneal ZnPP pump, occurrences of brain edema formation, and long term brain atrophy after ICH were significantly decreased （P〈0.05）. Conclusions Intraperitoneal ZnPP pump treatment is a new method of choice for managing ICH rats.