中文摘要：

目的：探讨医院感染病原菌耐药现状及中药与抗菌药物对耐药细菌感染疗效，以期为耐药细菌的控制、治疗提供参考。方法选择2014年3－12月发生医院感染的300例患者作为研究对象，分析病原菌种类及其耐药性；将58例耐药菌感染患者随机分为试验组和对照组，各29例，对照组仅用抗菌药物治疗，试验组在抗菌药物基础上配合使用丹参注射液；比较两组患者临床疗效和细菌清除率。结果300例患者共分离出497株病原菌，其中革兰阴性菌222株占44．7％，革兰阳性菌178株占35．8％，真菌97株占19．5％；铜绿假单胞菌对阿米卡星耐药率较低，大肠埃希菌、鲍氏不动杆菌对常用抗菌药物均显示出较高的耐药性；金黄色葡萄球菌对庆大霉素、利奈唑胺耐药率较低，表皮葡萄球菌对利奈唑胺耐药率较低，凝固酶阴性葡萄球菌对万古霉素耐药率较低；治疗1个疗程后，试验组总有效率为96．6％、对照组为89．7％，两组比较差异有统计学意义（ P＜0．05）；试验组细菌清除率为89．7％，对照组为75．0％，两组比较差异有统计学意义（ P＜0．05）。结论医院感染病原菌以革兰阴性菌为主，耐药现象较为严重；中药联合抗菌药物能够显著提高耐药菌感染治疗的临床疗效和细菌清除率，值得推广应用。

英文摘要：

OBJECTIVE To explore the current status of drug resistance of the pathogens causing nosocomial infec‐tions and observe the effect of traditional Chinese medicine combined with antibiotics on treatment of the infections due to drug‐resistant bacteria so as to provide guidance for control of the drug‐resistant bacteria .METHODS A to‐tal of 300 patients with nosocomial infections who were treated in the hospital from Mar 2014 to Dec 2014 were re‐cruited as the study objects ,then the distribution and drug resistance of the pathogens were analyzed;58 patients with drug‐resistant bacteria infections were randomly divided into the experimental group and the control group , with 29 cases in each;the control group was treated with single antibiotics ,while the experimental group was treated with additional danshen injections based on the antibiotics;the clinical curative effect and bacterial clear‐ance rate were observed and compared between the two groups of patients .RESULTS A total of 497 strains of pathogens have been isolated from the 300 patients ,including 222 （44 .7% ） strains of gram‐negative bacteria ,178 （35 .8% ） strains of gram‐positive bacteria ,and 97 （19 .5% ） strains of fungi .The drug resistance rate of the Pseudomonas aeruginosa to amikacin was relatively low ,the Escherichia coli and Acinetobacter baumannii were highly resistant to the commonly used antibiotics ;the drug resistance rates of the Staphylococcus aureus to genta‐micin and linezolid were relatively low ,the drug resistance rate of the Staphylococcus epidermidis to linezolid was relatively low ,and the drug resistance rate of the coagulase‐negative Staphylococcus to vancomycin was relatively low .One treatment course later ,the total effective rate was 96 .6% in the experimental group ,89 .7% in the con‐trol group ,and there was significant difference between the two groups （P〈0 .05）;the bacterial clearance rate was 89 .7% in the experimental group ,75 .0% in the control group ,and there was signifi