目的:评价香附四物汤与四物汤对急性血瘀SD大鼠模型血液流变性、凝血功能及卵巢功能的影响。方法:采用冰水浴及注射肾上腺素的方法造成SD大鼠急性血瘀模型,对其血液流变性、凝血4项及卵巢分泌功能进行测定。结果:香附四物汤能有效改善急性血瘀SD大鼠全血黏度、血沉、红细胞压积,延长TT、APTT,降低FIB至正常水平,对卵巢功能也显示一定改善作用;而四物汤对以上各指标影响不明显。结论:在对急性血瘀模型大鼠的生物效应评价中,香附四物汤优于四物汤。
Objective:To evaluate the effects of Xiangfu Siwu Decoction ( XFSW) and Siwu Decoction (SW) on hemorheological indexes and ovarian function in rat model of acute blood stasis.Method:A model of blood stasis was established by means of giving rats an injection of adrenalin and making them swim in ice-cold water.The indexes of hemorheology,TT,PT,APTT,FIB,E2 and P were detected.Results:XFSW showed improvements in the indexes of rats in the model of acute blood stasis,prolonged TT,APTT,degraded FIB to normal level and regulated the secretion of E2 and P.However,SW showed weak effects on these indexes.