中文摘要：

本研究建立了陡脉冲在均匀介质中的有限元模型，采用ANSYS电磁场软件仿真双电极和七电极阵列的二维电场强度分布，并改变脉冲参数（电压值、电极间距和电极直径），分析电场强度的分布规律。通过陡脉冲处理在体大白兔肝脏的实验，定量观察兔肝组织病理改变的几何区域、组织损伤的实际形状和电极的有效杀伤半径。结合理论仿真结果，探讨导致兔肝细胞不可逆性电击穿所需达到的电场强度阈值，为今后的临床应用寻找电极阵列布置和脉冲电参数选择的依据。

英文摘要：

This paper sets up finite element model of steep pulse field distribution in uniform medium to obtain the 2- dimension electric field distribution in different electrode arrays with ANSYS software. It analyzed different electric field distribution with the changed voltage, space between adjacent electrode and diameter of electrode respectively. In the rabbit liver in vivo experiment, we measured the geometry area of pathological changes, shapes of scathing tissue, and effective killing radius of electrode. Combined with simulation results, we got electric field intensity threshold which leads to the irreversible breakdown of rabbit liver cell, and found the reference for electrode arrays arrangement and pulse parameters selection in future clinical application.