中文摘要：

生物基因组中表观遗传学信息决定着表观基因型，为蛋白质的制造提供何时、何地、以何种方式行使遗传信息的指令。长期的分子生物学研究揭示了一系列袁观遗传学的改变与胃癌的发生、发展有关，这些改变涉及抑癌基因、细胞粘附分子、细胞周期调节因子和遗传不稳定性等，相关表观遗传学分子机制主要包括DNA甲基化、基因组印记异常表达、组蛋白异常乙酰化、microRNA改变等。利用MSP等方法检测胃癌患者血清中相关基因异常甲基化是一种具有较高灵敏度和特异性的方法，可以作为胃癌诊断的辅助手段。DNA甲基化抑制剂和组蛋白去乙酰化酶抑制剂联合使用，能够更有效地抑制肿瘤的生长，有可能成为治疗胃癌的新途径，具有一定临床应用价值。

英文摘要：

Epigenetic features of biological genome determines the epigenetic-type, which provides the instruction for the production of proteins. Long-term studies on the molecular biology have revealed the relationship between a series of changes in epigenetics and the occurrence of gastric cancer. These changes are related to suppressor genes, cell-adhesion molecules, cell cycle regulators, and genetic instability. The molecular mechanisms include DNA methylation, abnormal expression of genomic imprinting, abnormal histone acetylation, and microRNA changes. The detection method for the related gene aberrant methylation in the serum of patients with gastric cancer, such as MSP, is high sensitive and specific, valuable for the diagnosis of gastric cancer. The combined use of DNA methylation inhibitors and histone-deacetylase inhibitors is more effective to inhibit tumor growth and has the potential to become a new way to treat gastric cancer.