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Hemodynamic effects of stenting on wide-necked intracranial aneurysms
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  • 分类:TP391.41[自动化与计算机技术—计算机应用技术;自动化与计算机技术—计算机科学与技术] Q66[生物学—生物物理学]
  • 作者机构:[1]Department of Interventional Neuroradiology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, China, [2]Department of Mechanics and Engineering Science, Fudan University, Shanghai 200433, China, [3]College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100024, China, [4]Department of Biomedical Engineering, Capital Medical University, Beijing 100050, China , [5]Department of Biomedical Engineering, Capital Medical University, Beijing 100050, China
  • 相关基金:This study was supported by grants from the National Science Foundation of China (No. 30772234 and No. 10972016), the Natural Science Foundation of Beijing (No. 7072016 and No. 3092004), the Individual Item Assisted by Beijing Excellent Talents Program (No. 20061D0300400072), and High Level Health Technique Talent Training Plan of Beijing Health System (No. 2009-3-22).
  • 相关项目:颅内动脉瘤治疗后复发风险的三维血流数值模拟研究
中文摘要:

背景 Stent 放置广泛地被用来帮助在服的动脉瘤治疗卷。现在的学习试图在在 stenting 被创造前后,三理想化的有机玻璃 aneudsmal 与不同几何学建模的宽颈的 intracranial aneurysms.Methods 上调查 stenting 的血液动力学的效果,并且他们的三维的计算模型被构造。在 stented 和 unstented 的流动动力学动脉瘤的模型被学习在 vitro 使用流动可视化和计算液体动力学(CFD ) 模拟。另外,在一个病人特定的动脉瘤模型的流动动力学上的 stenting 的效果是也由 CFD.Results 分析了流动可视化的结果与那些与 CFD 模拟获得了一致。Stent 推广减少了旋涡里面动脉瘤囊上的动脉瘤和它的影响,和减少的墙砍 sac.Different 动脉瘤几何学上的应力越过动脉瘤的颈支配了 stenting.Conclusions Stenting 的根本上不同的血液动力学的模式和结果改进本地血流动侧面。这可以在动脉瘤便于血栓形成并且减少开运河的机会。

英文摘要:

Background Stent placement has been widely used to assist coiling in cerebral aneurysm treatments. The present study aimed to investigate the hemodynamic effects of stenting on wide-necked intracranial aneurysms.Methods Three idealized plexiglass aneudsmal models with different geometries before and after stenting were created, and their three-dimensional computational models were constructed. Flow dynamics in stented and unstented aneurismal models were studied using in vitro flow visualization and computational fluid dynamics (CFD) simulations. In addition, effects of stenting on flow dynamics in a patient-specific aneurysm model were also analyzed by CFD.Results The results of flow visualization were consistent with those obtained with CFD simulations. Stent deployment reduced vortex inside the aneurysm and its impact on the aneurysm sac, and decreased wall shear stress on the sac.Different aneurysm geometries dictated fundamentally different hemodynamic patterns and outcomes of stenting.Conclusions Stenting across the neck of aneurysms improves local blood flow profiles. This may facilitate thrombus formation in aneurysms and decrease the chance of recanalization.

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