中文摘要：

[目的]考察生附子醇提物的经口急性毒性。[方法]以70％为溶媒，用索氏提取法制备附子浸提物，经预试验获得正式试验最大给药剂量，设计7个剂量组，组间距1．7倍，给昆明系小鼠灌胃给药一次，剂量为0．04ml／（g·BW）．观察7d，用改良寇酗去公式计算半数致死量（LD50）及其95％可信限。[结果]附子醇提物给小鼠经口LD50为230．12mg（kg·BW），LD50的95％可信限为80．39～658．57mg/（kg·BW）。[结论]生附子醇提物可快速引起小鼠出现急性毒性。

英文摘要：

[Objective] This study aimed to investigate the acute oral toxicity of crude monkshood （Radix aconiti lateralis preparata）. [Method] Monkshood alcohol extract was prepared using soxhlet extractor. The maximum drug dose, which was the minimum dose causing 100% lethally rate in the preliminary test, was diluted into seven con- centrations in formal test. Then every mouse was orally administrated with 0.04 ml/g of the monkshood solution at single time for 7 d. Median lethal dose （LD50） and 95% confidence limit were calculated by the improved Karber method formulas. [Result] LD50 of monkshood ethanol extract was 230.12 mg/kg and 95% confidence limit of LD50 was 80.39-658.57 mg/kg. [Conclusion] Crude monkshood alcohol extract can quickly induce acute toxicity in mice.