中文摘要：

采用柱层析方法从银杏叶内生真菌Chaetomium globosum ZY-22的培养菌丝体提取物中分离得到脑苷脂B（1）、脑苷脂C（2）、尿囊素（3）、9（11）-去氢麦角甾醇过氧化物（4）以及4,6,8,22-四烯-3-酮-麦角甾烷（5）和球毛壳甲素（6）共6个次生代谢物;经波谱分析确定了6个化合物的结构,其中脑苷脂B、脑苷脂C和尿囊素是首次从内生真菌中得到;海虾致死试验结果显示,化合物1～6在10μg/mL浓度下对丰年虾的致死率分别为1.6%、4.2%、7.4%、16.9%、12.8%、83.6%、表明球毛壳甲素对海虾表现出很强的毒性作用.

英文摘要：

Six metabolites cerebroside B （1） ,eerebroside C （2） ,allantoin （3） ,9（ll）-dehyoergosterol peroxide （4） and ergosta-4,6,8,22-tetraen-3-one （5）, chaetoglobosin A （6） were isolated by column ehromatography from the extract of cultural mycelium of fungus Chaetomium globosum ZY-22, an endophyte in the leaves of Ginkgo biloba. Structures of them were established by spectroscopic methods. Among of them,cerebroside B,cerebroside C, allantoin were firstly obtained from endophytic fungus; The result of brine shrimp bioassay showed the mortality rates of them to Artemia salina are 1.6%, 4.2%, 7.4%, 16.9%,12.8% and 83.6% respectively at the concentration of 10μg/mL,chaetoglobosin A showed significant toxic effect on brine shrimp.