中文摘要：

烟酰胺磷酸核糖转移酶（Nampt）是哺乳动物细胞合成烟酰胺腺嘌呤二核苷酸的限速酶; Nampt也是一种细胞因子,如作为一种新的具有结合并激活胰岛素受体、模拟胰岛素作用的脂肪细胞因子,调控B细胞分化、延缓中性粒细胞凋亡、参与炎症和免疫应答.本文就Nampt的结构、功能及其与肿瘤关系的研究进展作一综述.

英文摘要：

Nicotinamide phosphoribosyltransferase （ Nampt ） is a rate-limiting enzyme for synthesis of nicotinamide adenine dinucleotide in mammalian cells. Recent studies show that Nampt also works as a cytokine that exerts insulin-mimetic effects by binding to the insulin receptor, induces B-cell differentiation, inhibits neutrophil apoptosis, and affects immune and inflammatory functions. This review is focused on current knowledge regarding the structure and function of Nampt and its roles in carcinogenesis.