中文摘要：

反义长链非编码RNA（10ngnon-codingRNA，lncRNA）是一类与其它转录物序列互补的内源性lncRNA。它们通过转录抑制、染色质重塑、核内RNA．RNA相互作用和胞浆RNA．RNA相互作用等机制，在转录及转录后水平调控靶基因的表达。反义lncRNA参与了X染色体失活、基因组印记及一些疾病的发生和发展过程，有希望成为疾病治疗的新靶点。

英文摘要：

Antisense long non-coding RNAs （IncRNAs） are non-coding RNAs with their sequences complementarily to other transcripts. This type of IncRNA regulates gene expression at either transcriptional or post-transcriptional level through a variety of biological mechanisms including transcription interference, RNA-DNA interaction （chromatin remodeling）, RNA-RNA interaction in the nucleus and in the cytoplasm. Antisense IncRNAs are involved in X-chromosome inactivation, genomic imprinting and some diseases＇ occurrence and development. At the same time, these mechanisms provide a theoretical basis for antisense IncRNA as a therapeutic target.