中文摘要：

目的：观察阿尔茨海默病（ AD）患者血浆淀粉样变程度、血清总胆固醇水平及全血黏度变化，并分析其相关性。方法 AD患者30例（观察组），健康对照人群30例（对照组），采用FL F-2500荧光分光光度计检测淀粉样纤维荧光强度，计算淀粉样纤维水平；LBY-N6A血流变仪检测血液流变学指标；TBA-120FR全自动生化仪检测血脂。多元线性回归分析法分析血浆淀粉样变程度、全血黏度（高切）、血清总胆固醇间的关系。结果观察组及对照组血浆淀粉样纤维水平分别为（16．63±5．67）、（12．83±0．27） U/mL，血清总胆固醇水平分别为（4．71±1．24）、（3．95±0．22）mmol/L，全血黏度（高切）水平分别为（4．16±0．54）、（3．74±0．15）mPa s，两组比较，P均＜0．05。多元线性回归分析显示，血浆淀粉样变程度、血清总胆固醇水平与全血黏度（高切）呈正相关趋势（ r分别为0．598、0．664，P均＜0．05）。结论 AD患者血浆淀粉样变程度、血清总胆固醇水平、全血黏度升高，前两者与后者呈正相关。

英文摘要：

Objective To observe the plasma amyloidosis degree , serum total cholesterol level and whole blood vis-cosity changes in patients with Alzheimer＆#39;s disease （ AD） , and to analyze their correlations .Methods Thirty cases of AD patients （observation group） and 30 cases of healthy controls （control group） were selected.The plasma amyloid fibril flu-orescence intensity was detected by FL F-2500 fluorospectro photometer , then we calculated the amyloid fibril levels;LBY-N6A rheology instrument was used to examine the hemorrheological parameters;and TBA-120FR automatic biochemical an-alyzer was used to test the blood lipid level .Multivariate linear regression analysis was used to analyze the relationships a-mong plasma amyloidosis degree , whole blood viscosity （ high shear part ） and serum total cholesterol .Results In the ob-servation group and control group , the plasma amyloid fibril levels were （16.63 ±5.67） and （12.83 ±0.27） U/mL, re-spectively;the whole blood viscosity （high） were （4.16 ±0.54） and （3.74 ±0.15） mPa＆#183; s, respectively;and the total cholesterol levels were （4.71 ±1.24） and （3.95 ±0.22） mmol/L, respectively （all P＆lt;0.05）.The multivariate linear regression analysis showed whole blood viscosity （ high shear part ） was positively correlated with plasma amyloidosis degree and serum total cholesterol level （r=0.598, 0.664;all P＆lt;0.05）.Conclusion Plasma amyloidosis degree, serum total cholesterol level and whole blood viscosity increase in AD patients , and the first two are positively correlated with the latter one.