中文摘要：

目的：建立人血浆中羟基红花黄色素A（HSYA）高效液相色谱（HPLC）测定法，考察HSYA在健康女性体内单次和多次给药后药动学。方法：12名健康女性受试者第1天单剂量静滴HSYA70mg，第2天起qd。连续6d，给药后用HPLC测定不同时间血药浓度．求得主要药动学参数。结果：单次和多次静滴HSYA在体内过程符合非房室模型，主要药动学参数：Cmax分别为（5．9±1．6）、（7．8±2．4）mg·L^-1;tmax分别为（1．17±0．29）、（1．00±0．00）h；AUC0-15分别为（23．2±2．5）、（27．2±7．6）mg·L^-1·h；AUC0-∞分别为（23．8±2．8）、（28．6±8．4）mg·L^-1·h；t1/2β分别为（2．96±0．23）、（4．4±1．4）h。结论：qd，连续7d，静滴HSYA70mg，药物在体内无蓄积，受试者耐受性良好。

英文摘要：

OBJECTIVE To study the pharmacokinetics of intravenous infusion injection of hydroxysafflor yellow A（HSYA） at multiple-dose and the determination of HSYA in Chinese healthy volunteers. METHODS The plasma samples of 12 healthy volunteers were collected after injecting 70mg intravenous infusion injection of HSYA once a day for 7 days and were deter mined by HPLC method. RESULTS The main pharmacokinetic parameters of HSYA after injection a sing dose（70mg）and multiple-dose were as follow：Cmax were （5. 9± 1.6）,（7.8±2.4） mg ·L^-1;AUC0-15were （23.2±2.5）,（27.2±7.6） mg ·L^-1; AU0-∞ ,were （23.8±2.8）,（28.6±8.4） mg·L^-1·h;tmax were （1. 17±0.29）,（1.00±0.00）h;t1/ 2β were （2. 96±0.23）,（4.4± 1.4）h. CONCLUSION There are no body cumulation after injecting 70 mg intravenous infusion injection of HSYA once per day for 7 days, the volunteers are safe.