中文摘要：

目的：探讨白细胞介素-1受体拮抗剂（interleukin-1 receptor antagonist,IL-1ra）基因型与冠心病（coronary heart disease,CHD）患者患慢性牙周炎（chronic periodontitis,CP）易感性的关系。方法：选取冠心病患者86例,其中冠心病伴慢性牙周炎患者45例,单纯冠心病患者41例。取颊黏膜拭子,提取DNA,采用序列特异引物聚合酶链反应（sequence specific primers-polymerase chain reaction,SSP-PCR）法测定IL-1RN内含子2/VNTR位点的基因型,比较各基因型检出率的差别,采用SPSS13.0软件包进行统计学处理。结果：IL-1RN内含子2/VNTR等位基因2在冠心病伴慢性牙周炎组的检出率显著高于单纯冠心病组,差异有统计学意义（χ^2=4.960,P=0.026）。结论：在冠心病患者中,IL-1RN内含子2/VNTR等位基因2可能与其慢性牙周炎的遗传易感性相关。

英文摘要：

PURPOSE： To investigate the correlation between interleukin-1 receptor antagonist （IL-1ra） genotype and chronic periodontitis in patients with coronary heart disease. METHODS： Genomic DNA was obtained from buccal swabs in 86 patients with coronary heart disease,of which 45 patients with chronic periodontitis, the other without chronic periodontitis. Genotypes of IL-1RN intron 2 VNTR were analyzed by SSP-PCR method. Then the differences in distribution of each genotype were analyzed with SPSS 13.0 software package. RESULTS： A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in patients with coronary heart disease and chronic periodontitis group （χ^2= 4.960,P=0.026）. CONCLUSION： IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in patients with coronary heart disease. Supported by National Natural Science Foundation of China （Grant No. 30560163） and Natural Science Foundation of Xinjiang Autonomous Region（Grant No.200521111）.