中文摘要：

目的研究巨噬细胞移动抑制因子（MIF）基因-173G〉C多态性与江苏人群卵巢癌遗传易感性的关系。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术,检测MIF-173G〉C多态性在130例卵巢癌患者和145例年龄相匹配正常对照者的频率和分布,比较不同基因型携带者患卵巢癌的危险性;通过分层分析探讨年龄、初潮年龄、产次、流产数及绝经状态对罹患卵巢癌的影响。结果与携带MIF-173GG基因型相比,携带MIF-173GC/CC基因型者罹患卵巢癌的风险降低了43.2%（OR=0.568,95%CI=0.323～0.997）。分层分析结果显示,产次0～1次、流产≥2次及已绝经的女性携带-173GC/CC基因型较携带GG基因型者罹患卵巢癌的风险降低尤为显著（产次0～1：OR=0.392,95%CI=0.179～0.860;流产≥2次：OR=0.394,95%CI=0.166～0.934;已绝经：OR=0.436,95%CI=0.221～0.861）。结论 MIF-173G〉C多态性可能与江苏人群卵巢癌的发生有关。

英文摘要：

Objective To investigate the association of migration inhibitory factor（MIF）-173G 〉C polymorphism and susceptibility of ovarian cancer in Jiangsu province. Methods The M1F-173G 〉C polymorphism was analyzed by PCR-restriction fragment length polymorphism method, in 130 patients with newly diagnosed ovarian cancer and 145 cancer-free controls frequency-matched by age. The risk factors for ovarian cancer were compared between carriers of different genotypes. Age, age at menarche, parity,number of abortions and menopausal status were further stratified to analyze their effects on the risk of ovarian cancer. Results Compared with the MIF-173GG genotype, the individuals with GC/CC genotypes had a significantly decreased risk for developing ovarian cancer（OR =0. 568, 95 % CI = 0. 323-0. 997）. The stratification analysis showed that the decreased risk associated with GC/CC genotypes was more pronounced in women with parity being 41（OR= 0. 392, 95% CI=0. 179-0. 860）, number of abortions ~2 （OR-----0. 394,95% CI=0. 166-0. 934）, and within menopausal status （OR=0. 436,95% CI=0. 221-0. 861）. Conclusion The MIF-173G〉C polymorphism may contribute to the etiology of ovarian cancer in Jiangsu province population.