中文摘要：

目的研究巨噬细胞移动抑制因子（MIF）基因-173G〉C多态性与江苏人群宫颈癌遗传易感性的关系。方法采用PCR-限制性片段长度多态性技术检测MIF-173G〉C多态性在455例宫颈癌患者和447例年龄相匹配正常对照者的频率和分布。比较不同基因型携带者患宫颈癌的危险性;通过分层分析探讨年龄、初潮年龄、初次生育年龄、产次、流产数及绝经状态对罹患宫颈癌的影响。结果病例组和对照组间MIF-173G〉C各基因型频率差异无统计学意义（P〉0.05）。分层分析结果显示,在不同年龄、初潮年龄、初次生育年龄、产次、流产数及是否绝经特征分层中,病例组与对照组各基因型频率差异仍无统计学意义。结论本研究未发现MIF-173G〉C多态性与江苏人群宫颈癌的发生存在统计学关联。

英文摘要：

Objective To investigate the association between the MIF-173G〉C polymorphism and cervical cancer susceptibility in Jiangsu province.Methods The frequency and distribution of the MIF-173G〉C polymorphism were analyzed in 455 patients with newly diagnosed cervical cancer（group A） and 447 cancer-free controls（group B） by PCR-restriction fragment length polymorphism method.The risk for cervical cancer was compared among different genotype carriers.The effects of age at menarche,initial child-bearing age,parity,number of abortions and menopausal status on the occurrence of cervical cancer were analyzed further.Results No significant difference in the frequency and distribution of the MIF-173G〉C polymorphism was found between two groups.ConclusionThere may be no significant relationship between the MIF-173G〉C polymorphism and cervical cancer susceptibility in Jiangsu population.