中文摘要：

Caspase-8 (CASP8 ) 在 apoptosis 起一个关键作用。我们由 genotyping 检验了是否 ? 652 六核苷酸的插入删除(6N ins/del ) 在 CASP8 倡导者区域的多型性在 406 个中国前列腺癌症病人和 408 匹配年龄的 cancerfree 控制的基于医院的盒子控制研究与前列腺癌症风险被联系。另外， 23 前列腺癌症纸巾为 CASP8 mRNA 表示被分析。我们为 6N ins/del 遗传型发现了显著地减少的前列腺癌症风险[调整机会比率(或)=0.68；95% 信心间隔(CI )=0.51-0.92 ] 并且 del/del 遗传型(OR=0.34；95% CI=0.19-0.63 ) 与 ins/ins 遗传型相比。6N del 等位基因与减少的前列腺癌症风险 dose-dependently 被联系(Ptrend = 0.001 ) 。RT-PCR 证明有 6N del 等位基因的个人与 ins/ins 遗传型比那些有更低的 CASP8 mRNA 层次(P = 0.024 ) 。这些调查结果建议 CASP8-652 6N ins/del 多型性可以在中国人之中影响危险性到前列腺癌症和还原剂前列腺癌症风险。

英文摘要：

Caspase-8 （CASPS） plays a key role in apoptosis. We examined by genotyping whether the -652 six-nucleotide insertion-deletion （6N ins/del） polymorphism in the CASP8 promoter region was associated with prostate cancer risk in a hospital-based case-control study of 406 Chinese prostate cancer patients and 408 age-matched cancerfree controls. Additionally, 23 prostate cancer tissues were analyzed for CASP8 mRNA expression. We found a significantly decreased prostate cancer risk for the 6N ins/del genotype [adjusted odds ratio （OR）=0.68; 95% confidence interval （C/）=0.51-0.92] and del/del genotype （OR=0.34; 95% CI=0.19-0.63） compared with the ins/ins genotype. The 6N del allele was associated dose-dependently with decreased prostate cancer risk （Ptrend = 0.001）. RT-PCR showed that individuals with the 6N del allele had lower CASP8 mRNA levels than those with the ins/ ins genotype （P = 0.024）. These findings suggested that the CASPS-652 6N ins/del polymorphism may affect the susceptibility to prostate cancer and reduce prostate cancer risk among Chinese men.