中文摘要：

抗菌与大众生活密切相关，药物或基因的有效传送对于现代医疗来说是个不可或缺的手段，而含胍聚合物在这两个方向部有其独特的性能，如胍类聚合物的杀菌方式是通过非特异性（静电）相互作用来实现的，从生物进化的角度来看，细菌很难对其产生抗药性．其次，胍基与细胞膜磷脂中的磷酸根“牢固”的双氮键相互作用，使其在药物或綦因的转运方面表现优秀．同时，含胍聚合物对哺乳动物细胞相应低的或无毒性也为其应用扫清了障碍．因此，本文基于现有的艾献资料，归纳了含胍聚合物的构建方式和方法、综述了其在微生物抑制、药物或基因转运领域的应用．

英文摘要：

Antimicrobial is closely related to public life and efficient delivery of drug and gene is an indispensable means for the modem medicine. However, guanidinium-rich polymer has particular function in antimicrobial and delivery, such as the bactericidal mode of guanidinium-rich polymer is the non-specific interaction--electrostatic interaction, which is the driving force of the movement for the process of guanidinium-rich polymer getting close to the cell membrane of microbes, and from the perspective of biological evolution, which make bacterial hard to evolve resistance. On the other hand, the tight double-hydrogen bonded structure between guanidino and phosphate in the cell membrane phospholipids is the foundation for guanidinium-rich polymer exhibiting excellent performance on delivery, which will be an important grasp for the guani- dinium-rich polymer and its carrying molecules entering the mammalian cell membrane. Moreover, relatively lower toxicity or nontoxicity of guanidinium-rich polymer for the mammalian cells remove the obstacle of applications. Therefore, this paper is based on available literature, sums up the fabrication methods of guanidinium-rich polymer, reviews the applications in microbial inhibition and delivery of drug or gene.