中文摘要：

利用酵母、线虫、果蝇、小鼠等模式生物进行的研究表明，细胞的衰老过程与氧化还原紧密相关．伴随衰老，细胞内GSSG水平升高，GSH、NADPH等水平降低，而氧化还原状态变化将直接影响蛋白质的功能，特别是氧化还原敏感的含巯基蛋白质的功能，从而影响细胞信号转导和细胞命运．氧化还原失衡可能是衰老发生的重要因素．本综述将从氧化还原平衡与衰老、氧化还原调控与信号转导及衰老、氧化损伤与衰老等方面阐述细胞氧化还原调控与衰老研究的最新进展，提出并探讨氧化还原平衡的维持、氧化还原平衡的系统调控及氧化还原调控的个体化等延缓衰老及健康衰老的新策略．

英文摘要：

Using yeast, nematodes, fruit flies, mice and other model organisms, many studies have shown that cellular senescence closely associated with redox events. Intracellular level of GSSG is increasing along with aging, while GSH and NADPH levels decrease. Redox changes will directly affect protein function, especially redox-sensitive cysteine-containing proteins, and further affect signal transduction and cell fate. Redox imbalance may be an important factor in aging process. In this review, we will summarize the latest progress in aging concerning redox balance, redox signal transduction and oxidative damage, and discuss new strategies in anti-aging and healthy aging, such as maintenance of redox balance, systemic regulation of redox status and individual redox treatment.