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A new aristolactam alkaloid from the stems of Dasymaschalon trichophorum
  • ISSN号:1672-3651
  • 期刊名称:Chinese Journal of Natural Medicines
  • 时间:2013.1.1
  • 页码:81-83
  • 分类:R284.1[医药卫生—中药学;医药卫生—中医学]
  • 作者机构:[1]Department of Pharmacy, The 306th hospital of PLA, Beijing 100101, China, [2]School of rra-ditional Chinese Materia Medica, Shenyang P-harmaceutical University, Shenyang 110016, China, [3]Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Be(jing 100850, China
  • 相关基金:This project was supported by the National Natural Science Foundation of China (No.81072546) and the Chi- nese PLA National Science Fund for Distinguished Young Scholars Grant during the 11th "Five-Year" Plan period (No.06J001).
  • 相关项目:新骨架抗肿瘤先导物Des-B/C高活性位点衍生物合成与评价
中文摘要:

试图学习混合物被各种各样的层析的方法孤立并且净化的 Dasymaschaon trichophorum Merr 方法的茎的化学成分。他们的结构根据分光镜的方法被阐明。结果五 aristolactam 碱被获得,他们的结构作为 10-amino-3,6-dihydroxy-2,4-dimethoxyphenanthrene-1-carboxylic 酸被识别酮(1 ) , enterocarpam-II (2 ) , oldhamactam (3 ) , goniopedaline (4 ) ,和 stigmalactam (5 ) 分别地。结论化合物 1 是新 aristolactam 碱,当时混合物 25 第一次从这个类被报导。

英文摘要:

AIM: To study the chemical constituents of the stem of Dasymaschaon trichophorum Merr.. METHODS: The com- pounds were isolated and purified by the methods of various chromatography. Their structures were elucidated on the basis of spectro- scopic methods. RESULTS: Five aristolactam alkaloids were obtained and their structures were identified as 10-amino-3,6-dihy- droxy-2,4-dimethoxyphenanthrene-l-carboxylic acid lactam (1), enterocarpam-II (2), oldhamactam (3), goniopedaline (4), and stig- malactarn (5), respectively. CONCLUSION: Compound 1 is a new aristolactam alkaloid, while compounds 2-5 are reported from this genus for the first time.

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