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Consortium for the Human Information and Neurocognitive Endophenotype （CHINE） in mainland China： An example from neurological soft signs for neuropsychiatric disorders

分类：TP393[自动化与计算机技术—计算机应用技术;自动化与计算机技术—计算机科学与技术] R749[医药卫生—神经病学与精神病学;医药卫生—临床医学]
作者机构：[1]Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academyof Sciences, BeijinglO0101, China
相关基金：supported partially by the Key Laboratory of Mental Health,Institute of Psychology, Project-Oriented Hundred Talents Programme (O7CX031003);the Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-YW-R-131);National Natural Science Foundation of China (30770723);National Outstanding Young Investigator Award (81088001);a grant from National Basic Research Programme of China (973 Program) (2007CB512302)

作者： CHAN Raymond C K[1]

关键词：精神障碍, 中国大陆, 神经, 茅根, 信息, 人力, 多维表达式, ICD, endophenotypes, neurological soft signs, neuropsychiatric disorders, mental health, China

中文摘要：

增加努力识别比 DSM 或需要诊断他们的 ICD 诊断标准宽广的 neuropsychiatric 混乱的交替的表情反映 neuropsychiatric 混乱的多维的表情可以为内在的 etiological 或调节因素预付搜索的成长一致。Endophenotypic 研究能被认为是最有希望的策略之一衔接在 genomic 复杂性和在 neuropsychiatric 混乱观察的 phenotypic 异质之间的差距。然而， endophenotype 研究的多数被在大陆中国的学者限制到我们的西方的对应物，几乎没被做并且开始。在这篇论文，我们催促需要建立一个潜在的中央协会让 endophenotypes 在大陆中国学习 neuropsychiatric 混乱。特别地，我们在为造协会跟随步骤说明神经病学的软符号的一个潜在的例子。

英文摘要：

Increasing efforts to identify alternate expressions of neuropsychiatric disorders that are broader than the DSM or ICD diagnostic criteria needed to diagnose them reflects a growing consensus that multidimensional expressions of neuropsychiatric disorders may advance the search for underlying etiological or modulatory factors. Endophenotypic research can be considered to be one of the most promising strategies to bridge the gap between genomic complexity and the phenotypic heterogeneity observed in neu- ropsychiatric disorders. However, the majority of endophenotype studies were limited to our western counterparts, very little has been done and initiated by scholars in mainland China. In this paper, we urge the need to establish a potential central consortium for endophenotypes to study neuropsychiatric disorders in mainland China. In particular, we illustrate a potential example of neu- rological soft signs in following the steps for building the consortium.

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