中文摘要：

有精神分裂症的约 60% 题目介绍次要的神经病学的符号(神经病学的软符号， NSS ) ，它包括畸形在感觉并且一个非特定的服的机能障碍的马达表演陈述语气。这些也是在有精神病的病人的健康个人和亲戚的现在，以显著地更低的率。在精神病的 NSS 的过量可以是为这混乱的潜在的 endophenotype，并且反映也位于一致地在精神病报导的认知赤字下面的一样的 neurodevelopmental 大脑机能障碍。证实是否必要标准为精神病为精制 endophenotype 要求了的神经病学、认知的机能障碍会，有病的协会，我们探索了某些神经病学、认知的赤字在影响个人共同发生的证据。这条证据建议马达机能障碍的符号可能对有精神病，他们在要求马达技巧的认知任务与机能障碍在被联系的病人特定。因此，他们可以为精神病形成有希望的候选人 endophenotype。

英文摘要：

Approximately 60% of subjects with schizophrenia present minor neurological signs （neurological soft signs, NSS）, which in- clude abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cog- nitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.