中文摘要：

目的观察克山病合并高血压患者血浆可溶性细胞黏附分子-1（sICAM-1）和可溶性E-选择素（sES）水平，分析其与收缩压（SBP）、舒张压（DBP）和左室射血分数（EF）的相关性。方法选取2007年调查的黑龙江省克山病病区富裕县在册的克山病患者，按是否合并高血压分为克山病组（n=14）和克山病合并高血压组（n=17），另以当地健康志愿者作为对照组（n=10）。收集各组的年龄、性别及病史等一般临床特征，测量其SBP和DBP，采用超声心动图测量EF值，采用双抗体夹心酶联免疫吸附试验（ABC—ELISA）法检测血浆sICAM-1和sES水平。结果克山病合并高血压组较对照组和克山病组患者血浆sICAM-1水平明显升高[（399．84±99．06）比（323．06±61．27）、（268．27±72．88）μg／L，P〈0．05或〈0.01]；对照组与克山病组比较，差异无统计学意义（P〉0．05）。3组血浆sES水平比较，差异无统计学意义[对照组为（76.31±23．17）μg／L，克山病组为（72．26±20．15）μg／L，克山病合并高血压组为（90．21±19．21）μg/L，F=3．236，P〉0．05]。同时，克山病合并高血压组的SBP和DBP明显高于克山病组[（169±27）比（121±10）mmHg，（102±17）比（81±6）mmHg，1mmHg=0．133kPa，F=6．376、4．300，P均〈0．01]；EF未见明显改变[（58±14）％比（55±14）％，F=0．789。P〉0．05]。相关分析显示，克山病患者血浆sICAM-1水平与SBP和DBP呈正相关（r=0．5406、0．4612，P均〈0．01），与EF未见明显相关性（r=0．0734，P〉0．05）。结论sICAM-1参与克山病合并高血压的发病过程，但是否能作为克山病合并高血压的风险评估指标还有待研究。

英文摘要：

Objective To investigate plasma level of soluble intercellular adhesion molecule-1 （sICAM-1） and soluble E-slectin （sES） in patients with Keshan disease （KD） accompanied by hypertension, and to further their relation to systolic blood pressure （SBP）, diastolic blood pressure （DBP） and ejection fraction （EF） of left ventricle. Methods Patients with Keshan disease investigated in 2007 in Fuyu County, Heilongjiang Province were divided into two groups according to whether they were accompanied by hypertension or not： KDP group （n = 17）, the patients were diagnosed as Keshan disease accompanied by hypertension; KDN group （n = 14）, the patients were only diagnosed as Keshan disease. Healthy volunteers lived in the same area as the patients were included in the control group （CON group, n = 10）. The clinical data （such as age, sex and past medical history）, SBP and DBP were recorded. EF was detected by echocardiography. Plasma slCAM-1 and sES concentrations were measured by ABC-enzyme-linked immunosorbent assay technique. Results Plasma level of sICAM-1 in the subjects was significantly elevated in KDP group as compared with that in CON group and KDN group [（399.84 ± 99.06） vs （323.06 ± 61.27） μg/L, P 〈 0.05; （399.84 ± 99.06） vs （268.27 ± 72.88） μg/L, P 〈 0.01]. However, there was no statistical significance in plasma sICAM-1 between the KDN group and control group （P 〉 0.05）. The difference of plasma sES between the control group, KDN group and KDP group did not reach statistical significance [（76.31 ± 23.17）, （72.26 ± 20.15） and （90.21 ± 19.21） μg/L, F = 3.236, P 〉 0.05]. As compared with the KDN group, SBP and DBP were obviously higher in KDP group [（169 ± 27） and （121 ± 10） mmHg, （102 ± 17） and （81 ± 6） mmHg, 1 mmHg = 0.133 kPa, F = 6.376, 4.300, all P 〈 0.01], and EF was not significantly increased [（58 ± 14）% and （55 ± 14）%, F = 0.789, P 〉 0.05]. Furthermore, correlation analysis showed pl