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Aberrant microRNA expression in the development of breast carcinoma
  • ISSN号：1001-6538
  • 期刊名称：科学通报(英文版)
  • 时间：0
  • 页码：3517-3526
  • 语言：中文
  • 分类：Q522[生物学—生物化学] S858.292[农业科学—临床兽医学;农业科学—兽医学;农业科学—畜牧兽医]
  • 作者机构：[1]State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China, [2]Department of Hygienic Analysis and Detection, School of Public Health, Nanjing Medical University, Nanjing 210029, China
  • 相关基金：This work was supported by the National Natural Science Foundation of China （60701008）.
  • 相关项目：高通量DNA测序片段的拼接
作者： Wu Qian|Lu JiaFeng|Lu ZuHong|Li HaiLing|Ge QingYu|
关键词： microRNA, 乳腺癌, 异常, miRNA, 生发, 小分子RNA, 非编码RNA, 抑癌基因, microRNA, breast cancer, tumorigenesis, invasion, metastasis
中文摘要：

microRNAs，小非编码的规章的 RNA 的一个班，涉及 oncogenesis 和癌症开发。研究证明了那异常 miRNA 表情发生在乳癌并且与特定的 clinicopathological 特征被联系。某 miRNAs 可能充当 suppressor 基因或 oncogenes，它能为乳癌诊断和同样预示的因素被看作新奇标记。这里我们在场 miRNAs 上的最近的发现的评论在乳癌包含了 tumorigenesis，侵略，和转移。

英文摘要：

microRNAs, a class of small non-coding regulatory RNAs, are involved in oncogenesis and cancer development. Studies have shown that aberrant miRNA expression occurs in breast cancer and is associated with specific clinicopathological features. Some miRNAs might act as suppressor genes or oncogenes, which can be considered as novel markers for breast cancer diagnosis and as prognostic factors. Here we present a review of recent discoveries on miRNAs involved in breast cancer tumorigenesis, invasion, and metastasis.

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