中文摘要：

黑素瘤是起源于表皮黑素细胞的一种高度恶性肿瘤.人端粒酶逆转录酶基因编码端粒酶的催化亚单位,该基因的表达参与细胞的永生化及肿瘤的发生发展,是决定端粒酶活性高低的主要因素.近年来研究发现,人端粒酶逆转录酶基因,特别是该基因启动子区的突变和甲基化状态与黑素瘤密切相关,目前人端粒酶逆转录酶基因与黑素瘤之间的关系已成为研究热点.

英文摘要：

Melanoma is a highly malignant tumor originating from epidermal melanocytes.The human telomerase reverse transcriptase （hTERT） gene,which encodes the catalytic reverse transcriptase subunit of telomerase,takes part in cellular immortalization as well as tumor occurrence and development,and is the major factor determining telomerase activity.Recent studies have shown that the hTERT gene,especially the mutations and methylation state of its promoter region,is closely related to melanoma.The relationship between the hTERT gene and melanoma has become a focus of current research.