中文摘要：

以脱氢枞胺为原料,在三氟乙酸酐和乙酸酐保护其氨基后,经B环铬酸氧化转化成为（酮）N-三氟乙酰基-7-氧代脱氢枞胺（2a）和N-乙酰基-7-氧代脱氢枞胺（2b）,酮再与盐酸氨基脲缩合形成（缩氨基脲）N-三氟乙酰基脱氢枞胺-7-氨基脲酰腙（3a）和N-乙酰基脱氢枞胺-7-氨基脲酰腙（3b）,然后在氯化亚砜的处理下发生Hurd-Mori反应,环合生成（B环并1,2,3-噻二唑衍生物）N-三氟乙酰基脱氢枞胺-6-烯[7,6-d]-并-1,2,3-噻二唑（4a）和N-乙酰基脱氢枞胺-6-烯[7,6-d]-并-1,2,3-噻二唑（4b）,最后在碱性条件下水解脱去氨基保护基,合成了脱氢枞胺-6-烯[7,6-d]-并-1,2,3-噻二唑（5）。通过FT-IR、1H NMR、13 C NMR和ESI-MS等方法对2a、3a、4a、4b和5的结构进行了表征,进一步分析了4a、4b和5这3种新型脱氢枞胺1,2,3-噻二唑衍生物的谱图特征及结构差异。

英文摘要：

Dehydroabietylamine,the starting material,reacted with trifluoroacetic anhydride and acetic anhydride to protect amino group,then converted to ketones： N-trifluoroacetyldehydroabietylamine-7-one（ 2a） and N-acetyldehydroabietylamine-7-one（ 2b）by oxidation on ring-B with chromic,the obtained ketones were treated with semicarbazide hydrochloride to afford semicarbazones：N-trifluoroacetyldehydroabietylamine-7-one semicarbazone（ 3a） and N-acetyldehydroabietylamine-7-one semicarbazone（ 3b）.Compounds 3a and 3b were transformed into ring-B fused 1,2,3-thiadiazole derivatives： N-trifluoroacetyldehydroabietylamine-6-ene[7,6-d]-1,2,3-thiadiazole（ 4a） and N-acetyldehydroabietylamine-6-ene[7,6-d]-1,2,3-thiadiazole（ 4b） by Hurd-Mori reaction with thionyl chloride. Finally,the amide were hydrolysised under alkaline condition to remove protecting groups,and gave dehydroabietylamine-6-ene[7,6-d]-1,2,3-thiadiazole（ 5）. The structures of three new synthesized dehydroabietylamine 1,2,3-thiadiazole derivatives 4a,4b and 5 were characterized by FT-IR,1H NMR,13 C NMR and ESI-MS. Their spectrum feature and structure difference were also analyzed.