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中文摘要：
从结构生物学角度研究蛋白质与蛋白质相互作用十分重要．核磁共振波谱技术是目前结构生物学的主要研究方法之一，该方法具有其他技术所不可替代的重要作用．核磁共振波谱技术可以在接近生理条件下研究蛋白质相互作用，特别适合研究瞬时存在的动态复合物．该技术是少数几种能够提供无结构或有部分结构的蛋白质以及蛋白质折叠过程等多方面信息的方法．核磁共振波谱技术还可以在多种时间尺度下提供蛋白质的动力学信息．本文以中国科学技术大学生物核磁共振波谱实验室的研究实例对上述观点进行阐述．
英文摘要：
Understanding protein interaction from the view of structural biology is important for understanding protein function in the cell. Nuclear magnetic resonance （NMR） is an important method in structural biology. To investigate molecular interactions by NMR spectroscopy is generally at a close physiological condition, This method particularly suites for studying transient dynamical complexes. NMR belongs to few techniques which can provide information for the unstructured or partial structured proteins. NMR also can provide information of protein dynamics in multiple-time scales. Here, we give some examples which come from research in our laboratory to illustrate the importance of NMR.
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