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重要细胞活动和生物分子识别的结构生物学基础
  • 项目名称：重要细胞活动和生物分子识别的结构生物学基础
  • 项目类别：创新研究群体科学基金
  • 批准号：30121001
  • 申请代码：C050102
  • 项目来源：国家自然科学基金
  • 研究期限：2002-01-01-2007-12-31
  • 项目负责人：施蕴渝
  • 负责人职称：教授
  • 依托单位：中国科学技术大学
  • 批准年度：2001
中文摘要：

中文主题词蛋白质结构和功能，细胞增殖与凋亡，氧化应激，细胞连接，蛋白质

中文主题词：
英文摘要：

protein structure and function

英文主题词： protein structure and function
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 188
  • 55
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期刊论文
Parametrization of a generaliz
Solution structure and DNA-bin
The Atomic Resolution Crystal
Identification for the hydroge
Interaction of Skp1 with CENP-
Solution structure of calponin
Jing Liu, Epitope mapping and
Phosphorylation of Pirh2 by Ca
Selective induction, purificat
SUMOsp: a web server for sumoy
Solution Structure of Human Br
Mitotic phosphorylation of PRC
Solution Structure of GOPC PDZ
Transcription of the putative
The treatment of solvation by
Investigation of the four coop
A genome-wide analysis of sumo
Nucleocytoplasmic shuttling of
Energetics of the electron tra
NEK2A interacts with MAD1 and
NBA-Palm: prediction of palmit
Construction of double-copy gl
2003. Polarized distribution o
Dynamic distribution of TTK in
p53-dependent apoptotic mechan
Quasi-equilibrium unfolding th
Comparative Molecular Dynamics
Yuhui Dong, Peng Liu，Expressi
A kinetic NMR study of reducti
Crystal structures and amidoly
Qiuhua Huang, Qinghua Zhang, S
Binding model of human coactos
Parallel iterative reaction pa
Adapting the nudged elastic ba
Genetic algorithms for protein
Nek2A kinase regulates the loc
TTK kinase is essential for th
Hydrogen Peroxide produced by
Crystal structure of the cyste
Efficiently explore the energy
Purification, N-terminal seque
Purification, partial characte
Nuf2 interacts with CENP-E and
Single-molecule detection of p
Use of DNA methylation for can
D-box is required for the degr
Determination of conformationa
Reaction path determination fo
The Crystal Structure of a Nov
Human Zwint-1 specifies locali
Structural genomics efforts at
Correlations between amino aci
Solution structure of the seco
Bcl-rambo beta, a special spli
Structural basis of protein _p
Expression, purification, crys
Crystal structure of human vac
Unique Structural Characterist
Co-crystallization of Leptospi
PALS1 specifies the localizati
Function of Arf6 in epithelial
Nek2A in chromosome segregatio
Investigation of the Structura
HSPPIP: An Online tool for pre
RIP3 beta and RIP3 gamma, two
GPS: a comprehensive www serve
Stabilization of PML nuclear l
ZComparison of protein interac
Triphenyl tin benzimidazolethi
The Blocking Effect and Crysta
NetAlign: a web-based tool for
Qun Liu, and Quan Hao, Crystal
Novel link between E2F1 and S
Acetylation of p53 at lysine 3
Proteomic identification and f
Human Yip1A specifies the loca
FBXL5 interacts with p150(Glue
Phosphorylation of Sgo1 by NEK
A novel genome-wide full-lengt
A novel short-chain peptide Bm
Crystal structure of Saccharom
Crystal structure of glutathio
Solution structure and metal b
The Bad Guy Cooperates with Go
Livin promotes Smac/DIABLO deg
Puma*Mcl-1 interaction is not
A general user interface for p
NMR structure and regulated ex
Cell biology of acid secretion
Myosin II is present in gastri
Function and regulation of Aur
Solution structure of BRD7 bro
Protein kinase TTK interacts a
Functions of spindle checkpoin
J How Good can we predict nati
Crystal structure of the yeast
Maize uroporphyrinogen III met
How does agkicetin-C bind on p
MeMo: a web tool for predictio
XAS atudy of a venom metallopr
p53 and Bad: remote strangers
An efficient site-directed mut
PKA-mediated protein phosphory
Improving metabolic flux estim
Nudel modulates kinetochore as
Expression of seven main Rho f
Solution structure of BmBKTx1
Experimentally obtaining the l
Compact molten globule-like st
. Suppression of tumor growth
Coling, expression, secondary
PPSP: Prediction of PK-specifi
CSS-Palm: Palmitoylation site
Purification, Mlecular charact
Functional Significance of Con
Etoposide upregulates Bax-enha
The antiangiogenic and therape
Mutation of arginines near the
PALS1 is essential for parieta
Nek2A specifies the centrosoma
GPS: a novel group-based phosp
Phosphorylation of ezrin on th
Siah-1Sa novel splice variant
HIV-1 TAT-mediated protein tra
Cleavage of RIP3 inactivates i
Death effector domain DEDa, a
Prediction of N-epsilon-acetyl
Direct interaction between sur
Mechanism of Munc18b-syntaxin
Expression, purification and p
COQ9, a new gene required for
Structure of Human Upstream Bi
van Gunsteren, WE, Molecular d
Crystal structures of E-coli l
Design and performance of U7B
Reversal of the malignant phen
Purification, crystallization
Ab initio QM/MM study shows th
Solution Structure of the Firs
cDNA cloning, expression, and
Characterization of protein ki
Progress and perspective of th
Phospho-regulation of HSCDC14A
A Bayesian-probability-based M
Cloning, expression, purificat
Crystal Structure of Uroporphy
哺乳动物驱动蛋白的计算基因组学分析与鉴定
短链蝎毒素BmK38的1^H—NMR谱峰归属、二级结构分析及溶液构象
核磁共振波谱研究蛋白质三维结构及功能
核磁共振波谱应用于结构生物学的研究进展
应用核磁共振波谱技术研究蛋白质相互作用
会议论文
Proteomic identification and f
Disruption of the parietal cel
Solution structure of Urm1 and
Chemical biological dissection
Epigenetic regulation of centr
Molecular dissection of mammal
Genomic stability and stem cel
Cell cycle regulation of SNARE
Molecular elucidation of prote
Proteomic dissection of metast
Proteomic dissection of chromo
Single molecule and nano-scale
Stabilization of PML nuclear l
Structures of E. coli Laccase
The particular structural chan
Molecular delineation of the k
Kinetochore assembly in mitosi
Proteomic and chemical biologi
Structural Study of a Nascent-
Study on the structure and fun
The Structure and Function of
Disruption of the parietal cel
Solution structure of Urm1 and
Chemical biological dissection
Epigenetic regulation of centr
Molecular dissection of mammal
ACAP4 interacts with ezrin and
Disruption of the parietal cel
Solution structure of Urm1 and
Chemical biological dissection
Epigenetic regulation of centr
Molecular dissection of mammal
ACAP4 interacts with ezrin and
Epigenetic regulation of centr
Molecular dissection of mammal
Proteomic dissection of human
Dissection of Chromosome insta
ACAP4 links membrane trafficki
Nek2A regulates the interactio
Molecular delineation of chrom
The Structural Characterizatio
ACAP4—ezrin interaction is es
Nek2a Regulates the Interactio
Functional of a novel ARF6 com
Structural genomics efforts fo
The purification and crystalli
Temporal Regulation of HsCdc14
PALS1 specifies the apical loc
CAP140, A Novel Microtubule-as
Molecular delineation of human
ACAP4 interacts with ezrin and
Disruption of the parietal cel
Solution structure of Urm1 and
Chemical biological dissection
ACAP4 interacts with ezrin and
施蕴渝的项目
核磁共振波谱技术及蛋白质空间结构预测方法研究
会议论文 8 著作 8
人的BET家族蛋白质Brd2,Brd4与组蛋白识别专一性的三维结构基础
期刊论文 19
细胞黏性连接及紧密连接处Nectin-AF-6系统及claudin-ZOs系统蛋白质相互作用的三维结构基础
期刊论文 15
在细胞粘附与迁移中协调多种小GTP酶的Arap3的结构与功能研究
RNA研究的若干重大科学问题
生物大分子核磁共振研究生暑期学校
ＣＩ阻遏蛋白和操纵基因的特异性相互作用
睾丸特有的核小体变体及其调控因子的结构与动力学研究
期刊论文 1
参加4th HOPE Meeting会议
用多维核磁共振波谱研究大鼠脑钠肽空间结构与功能
染色质结构改变相关蛋白质结构域三维结构与功能研究
期刊论文 2