中文摘要：

目的：研究老年高血压患者血浆同型半胱氨酸（HCY）与24h血压变异性（BPV）之间的关系。方法：随机选取2015年10月至2016年11月,在北京安贞医院高血压科住院的老年高血压患者217例,根据HCY水平将患者分为两组：高HCY组（HCY〉15.0μmol/L）115例及正常HCY组（HCY≤15.0μmol/L）102例。所有患者均行24h动态血压监测,计算24h收缩压及舒张压的变异系数,比较两组患者年龄、体质指数、血肌酐、血脂、空腹血糖、HCY、24h收缩压及舒张压的变异系数,并分析血压变异性与HCY的相关性。结果：高HCY组患者的年龄、空腹血糖、肌酐、HCY水平、24h收缩压变异系数和24h舒张压变异系数明显高于正常HCY组[（70.81±5.65）vs.（68.39±5.70）岁、（5.68±0.66）vs.（5.50±0.57）mmol/L、（81.13±19.80）vs.（72.38±13.85）μmol/L、（16.9±1.43）vs.（10.09±2.21）μmol/L、（11.57±2.33）vs.（10.51±2.31）、（11.74±2.46）vs.（10.47±2.08）],差异有统计学意义（P〈0.05）;老年高血压患者24h收缩压变异系数与HCY呈正相关（P〈0.05）;24h舒张压变异系数与HCY、CHO呈正相关,与HDL-C呈负相关（P〈0.05）。结论：老年高血压患者24h动态血压变异系数与血浆HCY水平正相关,血浆HCY升高可能是BPV升高的危险因素之一。

英文摘要：

Objective：To study the relationship between plasma homocysteine （HCY） and 24hour blood pressure variability （BPV） in elderly patients with hypertension.Methods：Totally 217 cases of hypertension in elderly hypertensive inpatients from October 2015 to November 2016 in Beijing Anzhen Hospital were randomly selected,according to the HCY level,the patients were divided into 2 groups：high HCY （HCY 〉15.0μmol/L） 115 cases and normal HCY group （HCY≤ 15.0μmol/L） 102 cases.All patients underwent 24 hour ambulatory blood pressure monitoring,calculate 24 hours systolic blood pressure and diastolic blood pressure variation coefficient,compared two groups of patients with age,body mass index,serum creatinine,blood lipid,fasting blood glucose,plasma homocysteine,24 hour systolic blood pressure and diastolic blood pressure variation coefficient,analysis the correlation of blood pressure variability and HCY.Results：The high HCY group of patients with age,fasting blood glucose,creatinine,HCY,24h systolic blood pressure variation coefficient and diastolic blood pressure variation coefficient was significantly higher than that in normal HCY group （70.81 ±5.65） vs.（68.39 ＆#177;5.70） years,（5.68 ＆#177;0.66） vs.（5.50 ＆#177;0.57） mmol/L,（81.13 ＆#177;19.80）vs.（72.38 ＆#177;13.85） pmol/L,（16.9 ＆#177;1.43） vs.（10.09 ＆#177; 2.21） μmol/L,（1 1.57 ＆#177; 2.33） vs.（10.51 ＆#177;2.31）,（1 1.74 ＆#177; 2.46） vs.（10.47 ＆#177; 2.08）,the difference was statistically significant （P 〈 0.05）;The coefficient of variation of systolic blood pressure of 24h in elderly patients with hypertension was positively correlated with HCY（P 〈 0.05）;24h diastolic blood pressure variation coefficient was positively correlated with HCY and CHO,and negatively correlated with HDL-C （P 〈 0.05）.Conclusion：The 24h ambulatory blood pressure variability coefficient is positively correlated with the plasma HCY level in elderly patients with hypertension,and the