中文摘要：

目的：探讨冠心病患者血浆白介素－35（IL－35）水平的变化与左室射血分数（LVEF）关系。方法：连续入选冠心病患者98例，其中稳定型心绞痛（SA）组（30例），不稳定型冠心病（UA）组（40例）和急性心肌梗死（AMI）组（28例）。同期冠脉造影正常的33例患者为对照组。采用夹心酶联免疫法（ELISA）测定血浆IL－35浓度。采用二维改良Simpson’s法测量LVEF。结果：与对照组相比，冠心病患者血浆IL－35水平显著降低，且UA组和AMI组血浆IL－35水平显著低于SA组。与对照组相比，SA组和AMI组LVEF显著降低。冠心病患者IL－35水平与LVEF显著正相关。结论：冠心病患者血浆IL－35水平可能与冠心病的发生及预后密切相关。

英文摘要：

Objective To investigate the relationship between plasma IL-35 and left ventricular ejection fraction （LVEF） in patients with coronary artery diseases （CAD）. Methods 98 patients with CAD were divided into 3 groups： stable angina （SA） group （n = 30）, unstable CAD （UA） group （n = 40） and acute myocardial infarction （AMI） group （n = 28）. 33 cases with normal angiographic results were included as control group. The plasma levels of IL-35 were measured by ELISA, and LVEF was quantified by the Biplane Simpson＇s method in 2-dimensionnal echocardiography. Results The plasma levels of IL-35 in patients with CAD were significantly lower than that in control group, and those in UA group and AMI group were lower than that in SA group. As compared to that in control group, the LVEF was lower in SA group and AMI group. Plasma level of IL-35 was positively correlated with LVEF in patients with CAD. Conclusion The plasma level of IL-35 may be related to the pathogenesis and prognosis of CAD.