中文摘要：

目的探讨小剂量两性霉素B脂质体对恶性血液病患者的安全性。方法回顾性分析解放军总医院血液科2013年6月-2015年4月收治的46例恶性血液病患者,其中男性33例,女性13例,平均年龄为39（17～77）岁。观察患者小剂量两性霉素B脂质体治疗前、后的肌酐（Cre）、尿素氮（BUN）及血钾（K^＋）水平,分析治疗后肌酐、尿素氮、血钾的变化情况。结果小剂量两性霉素B脂质体治疗后肌酐较治疗前升高4.24μmol/L,血钾较治疗前降低0.05 mmol/L,但均无统计学差异（P〉0.05）;尿素氮较治疗前升高0.94 mmol/L（P〈0.05）。结论小剂量两性霉素B脂质体的肾毒性发生率极低,对肌酐影响不明显,对尿素氮有一定影响,可使血钾降低,但差异无统计学意义。

英文摘要：

Objective To evaluate the potential toxicity of low dosage of liposomal amphotericin B on renal function and serum potassium in patients with malignant hematological disease. Methods A total of 46 patients with malignant hematological disease（33 male and 13 female with mean age of 39 years, range 17-77 years） from June 1, 2013 to April 30, 2015 in Chinese PLA General Hospital were enrolled in this study. The data of serum Cre, BUN, and potassium K＋ were collected before and after liposomal amphotericin B was given. The changes of serum Cre, BUN, and potassium K^＋ after treatment and the incidence of serum Cre, BUN, and potassium K＋ with change level more than 30% after treatment were analyzed. Results Compared with patients before treatment, the creatinine increased 4.24μmol/L and serum potassium decreased 0.05 mmol/L after treatment with low dosage of liposomal amphotericin B, but the difference were not statistically significant（P〉0.05）. While, urea nitrogen increased 0.94 mmol/L after treatment compared with patients before treatment with significant difference（P〈0.05）. Conclusion The incidence of toxicity to renal function in patients with low dosage of liposomal amphotericin B is quite low. There is no effect on serum creatinine, while it has a certain effect on serum urea nitrogen. And no significant difference is found in decreased potassium.