中文摘要：

人的脐的绳索血(CB ) 最近在移植被用作干细胞的来源。从 CB 导出的 NK 房间是涉及 graft-versus-host 疾病(GVHD ) 和 graft-versus-leukemia (GVL ) 的关键受动器房间。CB NK 房间的活动比成年的外部血(PB ) 的低，这被报导 NK cells.In 这研究，我们在 CB 和 PB NK 房间分析了一些 NK 房间受体和 cytotoxicity 相关的分子的表示。激活 NK 受体， CD16， NKG2D 和 NKp46 的表情，没显示出 CB 和 PB NK 房间之间的重要差别。但是禁止的受体 NKG2A/CD94 的表示在 CB NK 房间上是显著地更高的。至于受动器功能分子， granzyme B 被表示在表面 FasL 和小道没显示出的细胞内部的 perforin， IFN- ， TNF- 和房间的 CB NK 房间，而是表情显著地更低 CB 和 PB NK 房间之间的差别。结果显示 NKG2A/CD94 的高表示和 granzyme B 的低表示可能与 CB NK 房间的减少的活动是相关的。

英文摘要：

Human umbilical cord blood （CB） has recently been used as a source of stem cells in transplantation. NK cells derived from CB are the key effector cells involved in graft-versus-host disease （GVHD） and graft-versus-leukemia （GVL）. It was reported that the activity of CB NK cells was lower than that of adult peripheral blood （PB） NK cells. In this study, we analyzed the expression of some NK cell receptors and cytotoxicity-related molecules in CB and PB NK cells. The expressions of activating NK receptors, CD16, NKG2D and NKp46, did not show significant difference between CB and PB NK cells. But the expression of inhibitory receptor NKG2A/CD94 was significantly higher on CB NK cells. As to the effector function molecules, granzyme B was expressed significantly lower in CB NK cells, but the expressions of intracellular perforin, IFN-γ, TNF-α and cell surface FasL and TRAIL did not show difference between CB and PB NK cells. The results indicated that the high expression of NKG2A/CD94 and low expression of granzyme B may be related with the reduced activity of CB NK cells.