细胞焦亡(pyroptosis)是一种新的程序性细胞死亡方式,主要通过半胱天冬氨酸蛋白酶-1(caspase-1)来介导,并伴有大量的促炎性细胞因子的释放。在心力衰竭进展的不同阶段,细胞焦亡通过炎症小体活化及激活caspase-1参与心力衰竭的病理生理过程。本文就细胞焦亡在心力衰竭进程中的作用作一评述。
Pyroptosis is a newly identified form of programmed cell death mediated by caspase-1.It leads to inflammatory response through the release of pro-inflammatory cytokines.Pyroptosis participates in the pathophysiological progress of heart failure through inflammasome activation and activated caspase-1.