中文摘要：

检测系统性红斑狼疮（SLE）患者血清脱氧核糖核酸酶（DNase）的活性,探讨其在判断SLE疾病活动及狼疮肾炎（LN）中的临床意义。采集116例SLE患者、30例疾病对照者和30名健康体检者（对照组）的血清,用ELISA法定量检测血清DNase活性。结果表明：SLE患者血清DNase活性明显低于疾病对照组和健康对照组（P〈0.01）,且疾病活动期低于缓解期（P〈0.01）;DNase活性与SLE疾病活动程度呈负相关（P〈0.01）;狼疮肾炎组DNase活性低于SLE非狼疮肾炎组,两组比较有统计学意义（P〈0.05）。DNase活性下降可能是促进SLE及LN发生、发展的重要因素之一。血清DNase活性检测可用于判断SLE及其疾病活动程度的指标之一,同时也可作为判断LN的危险因素之一。

英文摘要：

To measure the activity of serum DNase in patients with systemic lupus erythematosus （SLE） and study the clinical significance on diagnosis of SLE and lupus nephritis （ LN）, as well as evaluating disease activity. The activity of DNase in sera which were collected from 116 patients with SLE and 30 patients with other autdimmune disease and 30 healthy individuals were detected by indirect ELISA. The results showed that the activity of serum DNase was significantly lower in patients with SLE than in patients with other autoimmune disease and healthy controls （ P 〈 0.01 ）, and it was also indicated that patients with active disease had statistically lower activity of serum DNase than patients without active disease （P 〈 0.01 ）. Moreover, the activity of serum DNase were negatively correlated with the SLE disease activity index （SLEDAI） （P 〈 0.01 ）. In addition, compared with SLE patients without nephritis, the activity of serum DNase in patients with LN was lower （ P 〈 0.05 ）. The results indicated that the activity of serum DNase is decreased in patients with SLE. The serum DNase could be a clinically useful parameter for the prediction of SLE disease activity and renal involvement.