中文摘要：

目的运用REHO技术探讨首发抑郁症患者静息态脑功能的变化。方法采用GE 3.0T磁共振成像仪对18例首发抑郁症患者和20例性别、年龄相匹配的正常志愿者进行静息态功能成像（fMRI）检查,排除全脑器质性病变,运用DPARSF、REST分析软件进行全脑分析。结果抑郁症患者与正常志愿者比较,抑郁症患者存在多个与认知及情绪控制相关脑区的自发神经活动异常,其中在左侧后扣带回、双侧颞下回、双侧颞上回、左侧到岛盖部额下回、左侧海马、左侧中央后回、左侧角回、右侧杏仁核、右侧眶内额上回、右侧补充运动区、右侧小脑后叶局部一致性减低（P〈0.05）。结论首发抑郁症患者静息态脑功能存在部分脑功能异常。这些脑区均与认知和情绪的控制密切相关。

英文摘要：

Objective To investigate the changes in brain regional homogeneity in first-onset major depressive disorders （MDDs） using resting-state functional magnetic resonance imaging （fMRI）. Methods Eighteen patients with first-onset MDDs and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional homogeneities of the brain regions. Results Compared with the normal controls, the patients with MDDs showed significantly decreased regional homogeneity in the left posterior cingulated gyms, bilateral inferior temporal gyrus, bilateral superior temporal gyms, left inferior frontal gyms, left hippocampa gyms, left posterior central gyms, left angular gyms, fight amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebeUar lobe. Conclusion Patients with first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.