中文摘要：

背景：重组人骨形态发生蛋白2能够有效促进新骨生成和骨折愈合,但其于腰椎融合的具体应用仍存在较多争论。目的：观察植入自体骨、重组人骨形态发生蛋白2复合骨在兔腰椎融合中的效果差异。方法：选取45只新西兰大白兔,构建腰椎后路横突间植骨融合兔模型,建模后随机分为3组,分别于兔L_5和L_6横突间位置植入自体髂骨、重组人骨形态发生蛋白2复合骨和异体髂骨。植入后正常喂养8周,麻醉后处死各组兔观察椎间融合情况。结果与结论：1与植入异体髂骨相比,植入自体髂骨和重组人骨形态发生蛋白2复合骨模型兔的手法检测融合率、影像学检查融合率、L_（5-6）/L_（4-5）椎体的拉伸强度比值及新生骨组织所占百分比均显著升高（P〈0.05）,且后2组上述各指标变化差异比较无显著性意义。2结果证实：兔腰椎入自体骨、重组人骨形态发生蛋白2复合骨后的融合效果相当,均优于异体骨。

英文摘要：

BACKGROUND： Recombinant human bone morphogenetic protein 2（rh BMP2） can effectively promote newbone formation and fracture healing, but its specific application in the lumbar spinal fusion remains controversial. OBJECTIVE： To study the effect of autogenous bone, rh BMP2 composite bone or allogeneic bone on the lumbarspinal fusion of rabbits. METHODS： Forty-five New Zealand white rabbits were enrolled to make intertransverse lumbar interbody fusion models and then randomly subjected to autogenous iliac bone, rh BMP2 composite bone or allogeneic iliac bone via L5-L6 intertransverse process, respectively. Then, the rats were sacrificed under anesthesia at 8 weeks after operation to observe the lumbar fusion. RESULTS AND CONCLUSION： Compared with the allogeneic iliac bone group, the fusion rates, tensile strengthratio of L5-6/L4-5, and percentage of new bone tissues were increased more significantly in the other two groups（P〈 0.05）, and moreover, there was no difference between the autogenous iliac bone and rh BMP2 composite bone groups. These findings indicate that the autogenous iliac bone and rh BMP2 composite bone have similar fusion effects, both of which are superior to the allogeneic bone.