中文摘要：

目的测定转化生长因子β1（transfergrowthfactorbetal，TGF-β1）在接尘工人血清中的表达水平，探讨其作为反映接尘暴露及尘肺早期诊断指标的可能性。方法采用双抗体夹心法，测定72例煤矿接尘工人（分为无尘肺0＋期组32人与接尘组40人）和45例健康对照者血清TGF-β1的表达水平。结果无尘肺0＋者血清TGF-B。含量为（59．71±7．74）ng／ml、接尘组为（48．45±5．45）ng／ml，对照组为（13．89±2．40）ng／ml。0＋期组、接尘组血清TGF-β1含量均高于对照组，差异有统计学意义（P〈0．05），0＋期组与接尘组差异亦有统计学意义，0＋期组与接尘组按工龄分层，各组内层之间差异无统计学意义。结论本次研究提示，TGF-β1可以作为监测粉尘暴露的指标，亦可做为早期筛查高危人群的指标。

英文摘要：

Objective To explore the serum level of TGF-β1 in dust exposed workers. Methods The serum levels of TGF-β1 in 72 dust exposed workers（ including 32 persons without pneumoconiosis in 0 ＋ stage and 40 people in dust exposed group） and 45 healthy individuals were detected by means of enzyme linked immunosorbent assay （ELISA）. Results The serum levels of TGF-β1 in 0 ＋ group were （59.71± 7.74） ng/ml, and in group of dust exposed were （48.45 ±5.45 ） ng/ml, the serum levels of control group were （ 13.89 ±2.40） ng/ml, there were statistically differences between the three groups; The serum levels of TGF- β1 in 0 ＋ group were higher than the other two groups （ P 〈 O. 05 ）. Conclusious TGF-β1 can be a sensitive index of dust exposure and early screening in high risk population.