中文摘要：

在哺乳动物系统中的可溶性环氧化物水解酶属于α/β水解酶类折叠家族的一个成员,它对环氧脂肪酸具有高度的选择性。环氧花生四烯酸或环氧二十碳三烯酸是其特异性底物。环氧二十碳三烯酸是内皮衍生超极化因子的主要组成成分。因此,环氧二十碳三烯酸具有舒张血管及降低血压作用,同时还具有抗炎、促进纤溶、调节血管生长等多种强大生物学效应,其水解酶的抑制剂—可溶性环氧化物水解酶抑制剂可以通过减少环氧二十碳三烯酸降解、增加环氧二十碳三烯酸水平从而模拟这些作用。因此,可溶性环氧化物水解酶抑制剂作为具有治疗高血压、动脉粥样硬化和炎症性疾病可能性的药物被广泛研究。

英文摘要：

The soluble epoxide hydrolase（sEH） in mammalian systems is a member of the α/β-hydrolase fold family of enzymes and it shows a high degree of selectivity for epoxides of fatty acids.The epoxides of arachidonic acid or epoxyeicosatrienoic acids（EET） are particularly good substrates.These EET appear to be major components of the endothelium-derived hyperpolarizing factors（EDHF）.As such,EET cause vasodilation and reduce blood pressure.The EET also have variable biological effects,such as anti-inflammatory,fibrinolysis,stimulating angiogenesis,etc.Whereas inhibitors of the regulatory enzyme—soluble epoxide hydrolase inhibitors（sEHi）,can increase the level of EET and mimic those effects.Therefore,sEH inhibitors are being extensively studied as a therapeutic potential for the treatment of hypertension,atherosclerosis,and inflammatory diseases.