中文摘要：

目的了解编织壳聚糖纤维的表征、降解及生物相容性。方法通过扫描电镜及密度、膨胀率、拉伸强度测定分析纤维的特征，黏度分析法测量鸡卵清溶菌酶对其降解作用，大鼠肌肉植入试验了解其体内吸收情况，大鼠骨髓基质干细胞培养了解其细胞毒性。结果纤维编织后直径2000±63μm，表面光滑，纤维密度1．093±0．270g／cm^3，膨胀率2．30±0．21，拉伸强度80．18±1．56MPa。加入溶菌酶2h内特性黏度下降约1／2，以后渐趋稳定。植入肌肉1周后炎症反应明显，随时间延长反应减退直至消失，4周时吸收不明显，12周大部分吸收。细胞生长情况良好，毒性试验阴性。结论壳聚糖编织纤维具有一定强度、良好的生物可降解性及生物相容性，适合构建骨或者软骨组织工程支架。

英文摘要：

Objective To investigate the characteristics, degradation and biocompatibility of a woven chitosan fiber （CF）. Methods .Scanning electron microscopic observation, deteronination of density, degree of swelling and tensile strength were performed to characterize the CF. In vitro degradation was observed by immersing CF in buffered aqueous solution of pH 6 containing lysozyme at 37 ℃, while in vivo degradation was studied after intramuscular implantation of CF in rats. Furthermore, rat mesenchymal stem cells were directly cultured on CF to estimate its toxicity. Results The diameter of CF was about 2000±63μm, with a sleek surface. The density and rate of swelling were 1. 093±0. 27g/cm^3 and 2.30±0.21, respectively. The tensile strength was 80. 18± 1.56MPa. Specific viscosity, measured after the addition of lysozyme to the solution, decreased dramatically within 2 hours compared with that of the control mixture without enzyme. There was obvious inflammatory reaction after intramuscular implantation in the first week after surgery, bat inflammation subsided gradually. Biodegradation was not obvious within 4 weeks, but majority of it was absorbed in twelve weeks. Cells grew well on it with normal morphology, and no inhibition of cell proliferation could be observed. Conclusion Woven CF has a good tensile strength and fairly good biodegradation and biocompatibility, and it can be used in bone and cartilage tissue engineering.