中文摘要：

目的 探讨精神病未治疗期（DUP）对首发未服药精神分裂症患者脑白质完整性的影响.方法 应用汉化的诺丁汉发病症状量表评定39例首发未服药精神分裂症患者的DUP,以其中位数为界将患者分为长DUP组和短DUP组,同时比较两组患者的性别构成、年龄、受教育年限、阳性和阴性症状量表总分.采用自旋回波序列得到弥散张量磁共振成像资料,以DTI-Studi0软件和统计参数图软件（SPM5）对所得图像进行预处理,得到的分子各向异性分数（FA）图像在SPM5软件中进行两样本t检验,获得两组FA差异统计参数图.结果 两组患者性别构成、年龄、受教育年限、阳性和阴性症状量表总分比较差异无统计学意义（P＞0.05）.在P值小于0.001（未校正）水平下,长DUP组患者大脑右侧前扣带束（x=8,y=40,z=24）和左侧前额叶白质（x=32,y=34,z=4）FA值较短DUP组降低.结论 延长的DUP会降低首发未服药精神分裂症患者脑白质的完整性.

英文摘要：

Objective To investigate the effects of duration of untreated psychiatry （DUP） on the white matter integrity in first-episode medication-free patients with schizophrenia. Methods The Chinese version of Nottingham Onset Schedule was used to assess the DUP of 39 first-episode medication-free patients with schizophrenia. According to the median of DUP, the 39 patients were grouped into long-DUP group and short-DUP group. Diffusion weighted images of the 39 patients＇ whole brains were acquired with a Half-Fourier Acquired Single-Shot Turbo Spin Echo （HASTE） sequence.After being preprocessed with DTI-studio and statistical parametric mapping software （SPM5）, the fractional anisotropy （FA） images of the 2 groups were compared by two-sample t-test with SPM5 software. The differences of gender, age, education level and total scores of Positive and Negative Syndrome Scale （PANSS） scores between the 2 groups were also detected. Results No significant difference was noted on gender, age, education level, PANSS scores between the 2 groups （P〉0.05）.Subjects of long-DUP group showed significantly reduced FA value in the right anterior cingulate fasciculus （x=8, y=40, z=24） and left prefrontal white matter thresholded （x=32, y=34, z=4） as compared with that of short-DUP group at a level of P〈0.001 （uncorrected）. Conclusion Extension of the duration of DUP will reduce the white matter integrity in first-episode medication-free patients with schizophrenia.