中文摘要：

甲型流感病毒M2蛋白属于跨膜蛋自，由97个氨基酸组成。M2蛋白作为一条H＋通道，对病毒的复制起醺要作用，而M2离子通道抑制剂类药物耐药性形势越来越严峻。M2胞质尾的特殊区域可能影响病毒装配。另一方面，M2蛋白外膜区（M2e）的高度保守性使对M2e疫苗的开发具有很大的前景一此艾就甲型流感病毒M2蛋白的研究现状作了综述：

英文摘要：

M2 protein of influenza A virus belongs to the membrane protein, is composed of 97 amino acids. M2 protein as an H^＋ channel plays an important role in the virus replication, the drug resistance of M2 ion channel inhibitors are increasingly grim situation. The special area of M2 cytoplasmic tail may affect the virus assembly. On the other hanoi, the development of M2 external domain （M2e）vaccine has great prospects because of the highly conservatism of M2e. In this review, the research progress of M2 protein is discussed.