中文摘要：

为调控骨组织工程支架的力学性能和降解性能,采用相分离方法,以冰醋酸-水为共溶剂配制聚合物溶液,以NaOH溶液为凝固剂,以CS为添加剂制备壳聚糖（CS）/聚己内酯（PCL）-聚乳酸（PLA）三维多孔支架,研究了聚合物质量比对支架结构、形貌、孔隙率、力学性能和降解性能的影响。实验结果表明,CS和基体存在相互作用,CS有利于形成三维相互贯通的微孔结构,但CS的存在会使基体中各组分的熔点降低。随着PCL和PLA用量比例的改变,孔径范围和微孔形貌发生了一系列的变化。当PCL∶PLA为2∶4和3∶3时,所制备的支架孔隙率均大于90%,当进一步增大PCL质量比时,孔隙率迅速下降。抗压测试表明,所制备的支架弹性模量为0.8～8.0 MPa。降解性能分析表明,4周以后,当PCL∶PLA为3∶3时,质量损失率最大,达到5.94%。该分析表明采用相分离法,通过调节PCL和PLA的质量比可制备形貌、孔隙率、降解速率和力学性能满足要求的三维多孔支架材料,有望应用在软骨组织工程上。

英文摘要：

The chitosan（CS）/poly（ε-caprolactone）（PCL）-poly（lactide）（PLA） scaffolds were prepared by phase separation method with the glacial acetic acid as the co-solvent for polymers,NaOH solvent as the quenching bath and chitosan（CS） as the additives.The effect of mass ratio on the structure,morphology,porosity,mechanical and degradation properties of the scaffolds was studied.The results show that there is a stronger interaction between CS and matrix.CS is beneficial for forming 3D interconnected micro-pore structure.The existent of CS can decrease the melting point of each component in the matrix.The pore size and microstructure morphology change with the mass ratio of PCL to PLA varied.The porosity reaches above 90% when the ratio of PCL∶PLA is 2∶4 and 3∶3,and decreases dramatically when further increasing the ratio of PCL.The compression test indicates that the elastic modulus of prepared scaffolds is between 0.8～8.0MPa.Degradation analysis indicates that when the ratio of PCL∶PLA is 3∶3,the mass loss reaches a maximum of 5.94% after 4 weeks.These results indicate that the fabricated scaffolds have a potential application for cartilage bone tissue engineering.The expectation 3D porous scaffolds with designable properties such as degradation speed,mechanical strength can be achieved through changing the ratio of PCL∶PLA by precipitation method.