中文摘要：

为制得在力学性能和生物活性方面都较为优异的羟基磷灰石（HA）复合涂层,首先,通过添加二元成骨微量元素化合物SrCO_3和SiO_2,以壳聚糖为造孔剂,采用电泳沉积的方法辅以高温烧结制得HA-SrCO_3-SiO_2复合涂层;然后,使用FTIR、XRD、SEM、EDS、万能材料试验机和电化学工作站对复合涂层进行测试与表征,并通过1.5倍离子浓度模拟体液的浸泡培养评价HA-SrCO3-SiO2复合涂层的生物活性。结果表明：HA-SrCO_3-SiO_2复合涂层与基体间的结合强度达28.6 MPa;在模拟体液中浸泡培养7d后,复合涂层表面完全碳磷灰石化,说明该复合涂层具有比单一掺杂成骨微量元素化合物复合涂层及纯HA涂层更为优异的生物活性。所得结论表明制得的HA-SrCO_3-SiO_2复合涂层有望开发成为新一代人工骨替代材料。

英文摘要：

In order to fabricate the hydroxyapatite（HA）composite coating which is more excellent in aspects of mechanical properties and bioactivity,HA-SrCO_3-SiO_2 composite coatings were fabricated firstly using electrophoretic deposition method aided with high temperature sintering by adding binary osteogenesis trace element compounds SrCO_3 and SiO_2,and using chitosan as porogen.Then,the composite coatings were tested and characterized by FTIR,XRD,SEM,EDS,universal material testing machine and electrochemical workstation,and the bioactivity of HA-SrCO_3-SiO_2 composite coatings was evaluated by immersion and cultivation in simulated body fluid of 1.5times ionic concentration.The results show that the bonding strength between HA-SrCO_3-SiO_2 composite coating and substrate reaches 28.6 MPa.After immersion and cultivation in simulated body fluid for 7d,the surface of composite coating is completely covered by carbonated hydroxyapatite,which indicates that the composite coating possesses better bioactivity than those of single osteogenesis trace element compound doped composite coating and pure HA coating.The conclusions obtained show that the prepared HA-SrCO_3-SiO_2 composite coatings would be developed as a brand generation of the artificial bone replacement material.