中文摘要：

目的了解贵州省织金县燃煤型氟中毒重病区儿童血液中锌、铁、钙、镁、铜、磷的变化情况。方法对织金县燃煤型氟中毒重病区5所小学6—15岁在校学生氟骨症患儿112例（病例组）、轻病区无氟骨症儿童92例（轻病区对照组），非病区儿童20例（健康对照组）进行血液中锌、铁、钙、镁、铜、磷及尿氟测定，并进行比较分析。结果病例组体内微量元素（锌、铁、钙、镁、铜）低于健康对照组（P〈0．05）；轻病区对照组介于病例组和健康对照组之间。重病区病例组儿童尿氟高于健康对照组，轻病区对照组介于病例组和健康对照组之间，但组间比较差异无统计学意义（P〉0．05）。病例组血磷高于健康对照组（P〈0．05）。结论高氟摄入可引起体内血锌、铁、钙、镁、铜的降低，血磷升高，同时使骨骼发生病变，严重影响儿童的生长发育。

英文摘要：

Objective To explore the changes of microelement and phosphorus in the body of children in fluorosis endemic areas of coal-burning type. Methods According to cohort stratified sampling method, serum iron, calcium, zinc, magnesium, copper and phosphorus were assessed in 112 school children with skeletal fluorosis aged 6 - 15 years in 5 primary .school in Zhijin county, Guizhou Province, 92 healthy children in mildly prevailing area and 20 normal controls in non-prevailing area. The results were compared. Results Serum iron, calcium, zinc, magnesium, copper was respectively higher in the healthy controls in the endemic areas compared with that in the experimental group （P 〈 0.05）, but still lower than the normal controls from non-prevailing areas. Urine fluorine in children from heavy endemic areas was higher than that in the normal controls, with that in the healthy controls in the endemic areas lying in between（P 〉 0.05 ）. The phosphorus level in the experiment group was higher than that in the normal control group （P 〈 0.05 ）. Conclusions Excessive fluorine intake may result in the decrease of serum iron, calcium, zinc, magnesium and copper and the increase of phosphorus, thus leads to skeletal fluorosis, which in turn affect the growth and the development of children.