中文摘要：

目的：研究益气养阴活血方对2型糖尿病（T2DM）胰岛素抵抗（IR）大鼠的影响。方法：采用高脂饮食4周后联合腹腔注射链脲佐菌素（STZ）建立2型糖尿病大鼠模型,随机分为模型组、津力达组及益气养阴活血方低、中、高剂量组,并设正常对照组,连续灌胃给药4周。检测比较各组空腹血糖（FBG）、血清胰岛素（INS）、糖化血清蛋白（GSP）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白（HDL-C）、低密度脂蛋白（LDL-C）含量,并计算胰岛素敏感指数（ISI）和胰岛素抵抗指数（HOMA-IR）。结果：与模型组相比,益气养阴活血方各剂量组FBG、INS、GSP、TC、TG、HDL-C水平均降低,ISI上升,HOMA-IR降低,差异均有统计学意义（P〈0.05或P〈0.01）。结论：益气养阴活血方能改善2型糖尿病胰岛素抵抗大鼠的糖脂代谢紊乱,从而改善胰岛素抵抗。

英文摘要：

Objective： To investigate the effect of qi-tonifying,yin-nourishing,and blood-activating prescription on insulin resistance（ IR） in rats with type 2 diabetesmellitus（ T2DM）. Methods： The high-fat diet for 4 weeks followed by intraperitoneal injection of streptozotocin（ STZ） was performed to establish a rat model of T2DM. The rats were randomly divided into model group,Jinlida group,low-,medium-,and high-dose qi-tonifying,yin-nourishing,and blood-activating prescription groups,and normal control group. The rats were treated by gavage for 4 consecutive weeks. The levels of fasting blood glucose（ FBG）,serum insulin（ INS）,glycosylated serum protein（ GSP）,total cholesterol（ TC）,triglyceride（ TG）,high-density lipoprotein cholesterol（ HDL-C）,and low-density lipoprotein cholesterol were compared between groups,and the insulin sensitivity index（ ISI） and homeostasis model assessment-estimated insulin resistance（ HOMA-IR） were calculated. Results： Compared with the model group,the qi-tonifying,yin-nourishing,and blood-activating prescription groups had significant reductions in the levels of FBG,INS,GSP,TC,TG,and HDL-C,a significant increase in ISI,and a significant reduction in HOMA-IR（ P〈0. 05 or P〈0. 01）.Conclusion： Qi-tonifying,yin-nourishing,and blood-activating prescription can improve dyslipidemia and IR in T2DM rats with IR.