中文摘要：

背景最近的研究建议了到主要压抑的混乱(MDD ) 的危险性可能与血清素 1A 受体(5-HTR1A ) 有关 C (-1019)G 多型性。在这研究，我们试图估计在 5-HTR1A C 之间的协会(在北哈特的 -1019)G 多型性和 MDD China.Methods 的种族组 C ( 5-HTR1A 的 -1019)G 与 MDD 和 400 无关的年龄在 400 个病人与聚合酶链反应( PCR )被检测--并且匹配性的健康控制题目。在 C 之间的协会( -1019)G 和 MDD 是统计上在那里的 analyzed.Results 是 MDD 病人之间的统计上重要的差别并且在两个控制遗传型分发( X2=10.913 ， df=2 ， P=0.004 )并且等位基因频率( X2=10.379 ， dr=l ， P=0.001 )，并且在遗传型分发和等位基因频率的重要差别在女题目被发现两个(遗传型分发: X2=15.406 ， df=2 ， P=0.000 ；等位基因频率：X2=15.552， df=l， P=0.000 ) 并且迟了发作的题目(遗传型分发: X2=7.771， df=2， P=0.021；等位基因频率：X2=8.007， df=l， P=0.005 ) 在二 groups.Conclusion，这些结果建议那 5-HTR1A C (-1019)G 多型性可能与 MDD 被联系，它是可能的是为女、迟了发作的 MDD 的易受影响的基因地点。

英文摘要：

Background Recent studies have suggested that susceptibility to major depressive disorder （MDD） might be related to the serotonin 1A receptor （5-HTR1A） C（-1019）G polymorphism. In this study, we aimed to assess the association between 5-HTR1A C（-1019）G polymorphism and MDD in the Northern Han ethnic group of China. Methods The C（-1019）G of 5-HTR1A was detected with polymerase chain reaction （PCR） in 400 patients with MDD and 400 unrelated age- and sex-matched healthy control subjects. Association between the C（-1019）G and MDD was statistically analyzed. Results There was a statistically significant difference between MDD patients and controls in both the genotype distribution （X^2=10.913, df=2, ,P=0.004） and the allele frequency （X^2=10.379, df=1, P=0.001 ）, and a significant difference in the genotype distribution and the allele frequency was found both in the female subjects （Genotype distribution： X^2=15.406, df=2, P=0.000; allele frequency： X^2=15.552, df=1, P=0.000） and the late-onset subjects （Genotype distribution X^2=7.771, df=2, P=0.021 ; allele frequency： X^2=8.007, df=1, P=0.005） in the two groups. Conclusion These results suggest that 5-HTR1A C（-1019）G polymorphism is probably associated with MDD and it is likely to be the susceptible gene locus for the female and late-onset MDD.