中文摘要：

目的探讨汉族健康人群5-羟色胺转运体基因（5-HTT LPR，5-HTT VNTR）、去甲肾上腺素转运体基因（NET T182C、NET G1287A单基因）及交互作用对人格的影响。方法严格按照入组标准筛取中国汉族健康人群367例，采用艾森克人格问卷（EPQ）测量人格的三个纬度，聚合酶链反应（PCR）检测5-HTT及NET基因多态性，使用SPSS13．0统计软件及多因子降维法（MDR）进行统计分析。结果①5-HTT VNTR各基因型及等位基因在人格维度间分布无差异（P〉0．05）。②神经质人格维度均数在5-HTT LPR各等位基因间分布有差异（t=2．232，P=0．026）。③内外向人格维度均数在NET T182C各等位基因间分布有差异（t=2．680，P=0．008）。④在内倾人格和外倾人格间，G1287A各基因型（χ^2=9．950，P=0．007）及等位基因（χ^2=9．644，P=0．002）分布差异有统计学意义，在其等位基因间，精神质人格维度均数分布有差异（t=3．226，P=0．001）。⑤未发现5-HTT LPR、5-HTT VNTR、NET T182C、NET G1287A间存在交互作用。结论①5-HTT VNTR可能与EPQ所测人格无关联。②5-HTT LPR与神经质人格相关，等位基因L是神经质人格的可疑危险因素。③NET T182C与内外向人格有关联，等位基因T是内倾人格的可疑危险因素。④NET G1287A与内外向、精神质人格相关，等位基因G是内倾人格的可疑危险因素；等位基因A是精神质人格的可疑危险因素。⑤尚未发现5-HTT、NET基因多态性间存在交互作用对人格产生影响。

英文摘要：

Objective To assess the interaction to personality among 5-HTT LPR,5-HTT VNTR, NET T182C,NET G1287A. Methods 367 Han Chinese healthy people were assessed with EPQ personality include P,E,N latitude. Using PCR to detect gene polymorphism include 5-HTT and NET. Using SPSS13.0 and MDR to do statistical analysis. Results （1）The distribution variance of the 5-HTT VNTR genetype and allele don＇ t have statistical significauce among different personality latitude （ P 〉 0.05 ）. （2）The mean T scores of N latitude＇ s have statistical significance among L/S allele（ t = 2. 232, P= 0. 026）. （3）The mean T scores of E latitude＇ s have statistical significance among T/C allele（ t=2.680, P=0. 008）. （4）The distribution variance of G1287A genetype（ χ^2 = 9. 950, P = 0. 007 ） and allele （ χ^2 = 9. 644, P = 0. 002 ） have statistical significance between different grades in E latitude. The mean T scores of P latitude＇ s have statistical significance among G/A allele（ t = 3. 226, P= 0. 001 ）. （5）There were no interaction among 5-HTT LPR, 5-HTT VNTR, NET T182C, NET G1287A. Conclusions （1） There were no associations between the 5-HTT VNTR and EPQ personality latitude. （2）5-HTT LPR have associations with N latitude. L allele is the doubtful risk factor of neurotic personality. （3）NET T182C have associations with E latitude. T allele is the doubtful risk factor of introvert personality. （4）NET G1287A have associations with E and P latitude. G allele is the doubtful risk factor of introversion personality. A allele is the doubtful risk factor of psychoticism personality. （5）There were no interaction to personality among 5-HTT, NET genes polymorphisms.