中文摘要：

高效抗逆转录病毒治疗（HAART）能有效地抑制人类免疫缺陷病毒（HIV）复制,大大降低获得性免疫缺陷综合征（艾滋病,AIDS）的患病率和病死率,却无法彻底清除病毒,进而发展为慢性病毒感染性疾病。慢性HIV感染破坏宿主免疫系统导致肠屏障破坏、肠黏膜功能紊乱及菌群易位加快疾病进程。而重建肠道微生态平衡和改善肠黏膜功能对重建宿主免疫系统至关重要。以下综述近年来关于艾滋病相关肠屏障损伤及其靶向治疗的研究进展,为进一步研究和改进艾滋病治疗措施、降低HIV感染患病率和病死率提供参考。

英文摘要：

Highly active antiretroviral therapy（HAART） can effectively suppress thehuman immunodeficiency virus（HIV） replication andsignificantly reduce morbidity and mortality of HIV-infectedpatients, which howevercan＇t completely remove the virus, and eventually progressinto chronic viral-infection disease.Chronic HIVinfection destroys host immune system, leading to intestinal barrier damage, intestinal mucosal dysfunction, microbial translocation,and further accelerates the disease progress.The reconstruction of intestinalmicroflora balance and improvement of intestinal mucosa function areessential to reestablish the host immune system. This paper will review the current research advanceson intestinal barrier damage of HIV infection and gut-target therapy of AIDS. The aim is to provide valid evidences for further research targeting improvement of treatment strategiesandreduction of morbidity and mortality in HIV infection.