中文摘要：

目的观察p38蛋白激酶（p38mitogen-activatedproteinkinase，p38MAPK）在癫痫大鼠脑内的表达情况。方法健康雄性SD大鼠随机分成正常对照组（n=8）和癫痫组（n=8）。采用戊四氮腹腔注射建立癫痫模型，大鼠点燃后的惊厥行为按照Racine的标准进行观察评分，采用Westernblot和免疫荧光法比较两组大鼠脑内p38MAPK的表达情况。结果癫痫组大鼠脑内p38MAPK在皮层和海马的表达均显著高于正常对照组（P〈0．01）。结论p38MAPK在癫痫大鼠脑内表达上调。

英文摘要：

Objective To investigate the expression of p38 mitogen-activated protein kinase （p38 MAPK） in cerebra of rat with epilepsy. Methods Healthy male SD rats were randomly divided into normal （n = 8） and epilepuc group （n=8）. Epilepsy model was established with the intraperitoneal injection of pentylenetetrazol. Behaviors were classified according to the criteria of Racine. The expression of p38 MAPK in cerebra was observed by immunofluorescence and Western blot. Results Compared with the normal rats, the expression of p38 MAPK in cortex and hippocampus of epileptic rats was significantly higher （P〈 0.01）. Conclusions The expression of p38 MAPK was up-regulated in cerebra of epileptic rats.