中文摘要：

目的建立一测多评（QAMS）的泽泻多指标质量控制方法，并验证该方法在泽泻含量测定中应用的可行性和技术适应性。方法采用HPLC，以25-乙酰泽泻醇B为内参物，计算泽泻醇A、24-乙酰泽泻醇A和泽泻醇B的相对校正因子，并利用该校正因子计算含量，同时与采用外标法测定4个三萜类成分的含量进行比较。结果建立的校正因子重现性良好，31批泽泻药材中4个三萜类的含量计算值与外标法实测值间（RSD≤3．52％）无显著差异。结论本实验所建立的一测多评法稳定、准确，可用于泽泻三萜类成分的质量控制。

英文摘要：

OBJECTIVE To develop a simultaneous quantitative analysis method of four triterpenoids in Alismatis Rhizoma by multi-components by single maker （QAMS）. METHODS Four main triterpenoids （ alisol A, alisol A 24-acetate, alisol B and alisol B 23-acetate） were selected as analytes to evaluate the quality of Alismatis Rhizoma. Alisol B 23-acetate was used as the internal refer- ence standard and three relative correction factors （RCFs） to alisol B 23-acetate were calculated. These RCFs were obtained by high performance liquid chromatography coupled with diode array detector under various chromatographic conditions. Then 31 batches of A1- ismatis Rhizoma samples collected from different areas were determined by both external standard method （ESM） and QAMS. RE- SULTS The RCFs were obtained with good reproducibility （ RSD ≤ 2.25% ）. No obvious differences were observed between the analysis results of QAMS method and ESM method （ RSD ≤3.52% ）. CONCLUSION The established QAMS method is reliable and feasible for simultaneous analysis of four triterpenoids and could be used for quality control of Alismatis Rhizoma. KEY WORDS ： Alismatis Rhizoma ; triterpenoids ; QAMS ; quality control