中文摘要：

目的：通过检测子宫内膜息肉患者外周血辅助性T细胞（ Th）中Th1／Th2平衡状态，探讨Th1／Th2与子宫内膜息肉的相关性。方法对25例子宫内膜息肉患者（ A组）行宫腔镜下定位诊刮活检，病理诊断为子宫内膜息肉；选择20例孕前检查妇科阴道B超未见异常的健康女性（ B组）。对两组均在非月经期抽取空腹肘静脉血，A组宫腔镜术前取血。采用三色荧光标记法流式细胞技术检测两组受检者外周血Th0细胞（ CD4＋IFN-γ＋IL-4＋）、Th1细胞（ CD4＋IFN-γ＋IL-4－）／Th2细胞（ CD4＋IFN-γ－IL-4＋）。结果两组中Th0细胞比较无显著性差异（P＞0．05）。 A组Th1细胞（33．33＆#177;8．68）％明显高于B组（22．35＆#177;3．88）％，经比较有显著性差异（t＝5．658，P＜0．05）；A组Th2细胞（3．25＆#177;0．89）％低于B组（3．72±0．79）％，但经比较无显著性差异（P＞0．05）；A组Th1／Th2比值（11．41±6．10）较B组（6．24±1．69）升高，经比较有显著性差异（t＝4．047，P＜0．05）。结论子宫内膜息肉与Th1／Th2平衡状态有一定的关联，这为研究子宫内膜息肉的发生机制提供了新的思路。

英文摘要：

Objective To investigate the relationship between Th1/Th2 lymphocyte balance in peripheral blood and endometrial polyps. Methods There were 25 women with endometrial polyps and diagnosed by pathology （ group A） accepting hysteroscopic curettage biopsy. Without abnormal change in gynecological ultrasound results, another 20 healthy women receiving pre-pregnancy check without abnormal ultrasonic results were selected （ group B） .Fasting venous blood was sampled from all cases during non-menstrual period, and in group A blood samples were colleted before hysteroscope operation.The distributions of Th0 cells （ CD4＋IFN-γ＋IL-4＋） and Th1 （ CD4＋IFN-γ＋IL-4-）/Th2 （ CD4＋IFN-γ-IL-4＋） were determined by 3-colored fluorescence labeled flow cytometry in two groups.Results The level of Th0 cells was not significantly different between two groups （P〉0.05）.The level of Th1 cells in group A was 33.33 ＆#177;8.68%, which was significantly higher than that in group B （22.35±3.88%） （t=5.658,P〉0.05）.The level of Th2 cells in group A was lower than that in group B （3.25±0.89%, 3.72 ±0.79%）, but the difference was not significant （P〈0.05）.Compared with group B, Th1/Th2 ratio was obviously higher in group A （11.41 ±6.10, 6.24 ＆#177;1.69） （t=4.047,P＆lt;0.05）.Conclusion There is a correlation between endometrial polyps and the balance of Th1/Th2, which provides new idea in studying the mechanism of endometrial polyps.